Endocannabinoids

fatty acid amide hydrolase ; Homo sapiens







82 Article(s)
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1 34051704 A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults. 2022 Mar 1
2 34496065 Genetic variation in endocannabinoid signaling is associated with differential network-level functional connectivity in youth. 2022 Mar 2
3 34756920 Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells. 2022 Feb 3
4 34830856 The Endocannabinoid System as a Pharmacological Target for New Cancer Therapies. 2021 Nov 15 2
5 32551466 Non-opioid Analgesics and the Endocannabinoid System 2020 Oct 23 1
6 32987725 Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors. 2020 Sep 24 1
7 30226747 FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug. 2019 Jan 16 1
8 31407888 New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation. 2019 Dec 26 2
9 28150397 Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. 2018 Jan 1
10 29695817 Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors. 2018 Apr 26 3
11 29729263 Enhanced endocannabinoid tone as a potential target of pharmacotherapy. 2018 Jul 1 2
12 30114402 Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS. 2018 Oct 1
13 27989417 1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability. 2017 Feb 1 2
14 26505525 Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold. 2016 Jan 20 2
15 26808012 Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer. 2016 Feb 1
16 27000802 Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes. 2016 Jun 1
17 27309570 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents. 2016 Jul 14 2
18 27582708 Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems-A Novel Treatment Option for Chronic Pain Management. 2016 2
19 27806235 Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase. 2016 Nov 3 1
20 25519724 A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells. 2015 Feb 1
21 25731744 FAAH genetic variation enhances fronto-amygdala function in mouse and human. 2015 Mar 3 1
22 26082009 Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [(11)C]CURB. 2015 Nov 2
23 26263913 Inhibition of FAAH confers increased stem cell migration via PPARα. 2015 Oct 2
24 26408159 The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review. 2015 1
25 26413912 Fatty acid amide hydrolase inhibitors: a patent review (2009-2014). 2015 2
26 26561012 Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. 2015 2
27 24705380 Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia. 2014 1
28 25283614 Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent. 2014 Dec 15 1
29 22688188 Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. 2013 Jul 1
30 23333123 Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet. 2013 May-Jun 1
31 23344792 The interaction of fatty acid amide hydrolase (FAAH) inhibitors with an anandamide carrier protein using (19)F-NMR. 2013 Apr 1
32 24223930 Role of FAAH-like anandamide transporter in anandamide inactivation. 2013 1
33 24445122 Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients. 2013 Dec 1
34 21442624 Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retinal pigment epithelial cells. 2012 Feb 1
35 21930339 Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats. 2012 Jan 2
36 22133920 Inhibition of fatty acid amide hydrolase (FAAH) reduces spinal nociceptive responses and expression of spinal long-term potentiation (LTP). 2012 Feb 10 2
37 22146559 Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity. 2012 Feb 15 1
38 22609216 Relationship among metabolic syndrome, C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance. 2012 Jul-Aug 2
39 22624680 Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT. 2012 Nov 1
40 22701012 Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes. 2012 Aug 1
41 22776995 A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity. 2012 Dec 4
42 21501143 The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake. 2011 Nov 1
43 21505060 Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. 2011 Jul 1
44 21631410 Fatty acid amide hydrolase inhibitors--progress and potential. 2011 Aug 1
45 21645511 Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase. 2011 Sep 30 1
46 21666860 Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. 2011 Feb 10 1
47 21924613 Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain. 2011 Nov 1 2
48 22295023 385 C/A polymorphism of the fatty acid amide hydrolase gene is associated with metabolic syndrome in the Chinese Han population. 2011 Jun 2
49 20044928 Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. 2010 Jan 1 1
50 20056290 C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2. 2010 Apr 1