| 1 |
33970224 | CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors. | 2022 May 6 |
2 |
| 2 |
35506379 | Abnormal Cyclic Nucleotide Signaling at the Outer Mitochondrial Membrane In Sympathetic Neurons During the Early Stages of Hypertension. | 2022 Jul |
1 |
| 3 |
30835157 | Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice. | 2019 May |
1 |
| 4 |
31100470 | PDE2 regulates membrane potential, respiration and permeability transition of rodent subsarcolemmal cardiac mitochondria. | 2019 Jul |
4 |
| 5 |
31121256 | Effect of phosphodiesterase (1B, 2A, 9A and 10A) inhibitors on central nervous system cyclic nucleotide levels in rats and mice. | 2019 Oct |
1 |
| 6 |
31253692 | Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat. | 2019 Sep |
7 |
| 7 |
31521738 | TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models. | 2019 Dec 30 |
2 |
| 8 |
29440309 | Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N-Methyl-d-Aspartate Receptor Antagonist-Induced Rat Models of Schizophrenia. | 2018 Apr |
2 |
| 9 |
29720569 | Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity. | 2018 May 3 |
4 |
| 10 |
30051530 | 17β-Estradiol reduces mitochondrial cAMP content and cytochrome oxidase activity in a phosphodiesterase 2-dependent manner. | 2018 Oct |
1 |
| 11 |
30651902 | Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats. | 2018 |
1 |
| 12 |
28283839 | Selective phosphodiesterase-2A inhibitor alleviates radicular inflammation and mechanical allodynia in non-compressive lumbar disc herniation rats. | 2017 Jul |
1 |
| 13 |
25916722 | Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons. | 2015 Jul |
1 |
| 14 |
25939307 | Angiotensin-converting enzyme inhibition prevents myocardial infarction-induced increase in renal cortical cGMP and cAMP phosphodiesterase activities. | 2015 Aug |
1 |
| 15 |
26178667 | Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus. | 2015 Oct |
2 |
| 16 |
24184653 | Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain. | 2014 Feb |
2 |
| 17 |
24424715 | Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. | 2014 May |
11 |
| 18 |
24531807 | PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways. | 2014 Apr 15 |
5 |
| 19 |
24837549 | Phosphodiesterase 2 negatively regulates adenosine-induced transcription of the tyrosine hydroxylase gene in PC12 rat pheochromocytoma cells. | 2014 Jul 5 |
4 |
| 20 |
24899690 | Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension. | 2014 Aug 5 |
2 |
| 21 |
23597790 | Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy. | 2013 Jun 1 |
2 |
| 22 |
23810893 | Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. | 2013 Oct 22 |
5 |
| 23 |
21330599 | cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. | 2011 Apr 15 |
7 |
| 24 |
21653225 | cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle. | 2011 Aug |
2 |
| 25 |
20139324 | Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases. | 2010 Apr |
1 |
| 26 |
20196107 | Expression and function of phosphodiesterases in nitrofen-induced congenital diaphragmatic hernia in rats. | 2010 Apr |
2 |
| 27 |
20213343 | Cyclic GMP and nitric oxide synthase in aging and Alzheimer's disease. | 2010 Jun |
2 |
| 28 |
21151982 | Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II. | 2010 Dec 3 |
5 |
| 29 |
19632989 | Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes. | 2009 Sep 18 |
2 |
| 30 |
18499090 | The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging. | 2008 Jun 24 |
1 |
| 31 |
18501878 | NO-mediated cGMP synthesis in cultured cholinergic neurons from the basal forebrain of the fetal rat. | 2008 Jun 27 |
2 |
| 32 |
18655195 | In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats. | 2008 Nov 15 |
7 |
| 33 |
18684888 | cGMP decreases surface NKCC2 levels in the thick ascending limb: role of phosphodiesterase 2 (PDE2). | 2008 Oct |
5 |
| 34 |
18957291 | Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion. | 2008 Dec 14 |
3 |
| 35 |
17141339 | Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages. | 2007 Feb |
4 |
| 36 |
17302738 | Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2. | 2007 Mar |
3 |
| 37 |
17407767 | Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures. | 2007 May 29 |
1 |
| 38 |
16621444 | ANP-mediated cGMP signaling and phosphodiesterase inhibition in the rat cervical spinal cord. | 2006 Jun |
1 |
| 39 |
15599707 | Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin. | 2004 Dec |
1 |
| 40 |
12834273 | cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles. | 2003 May |
1 |
| 41 |
12003819 | Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population. | 2002 Jun |
3 |
| 42 |
12065724 | Hydrolysis of N-methyl-D-aspartate receptor-stimulated cAMP and cGMP by PDE4 and PDE2 phosphodiesterases in primary neuronal cultures of rat cerebral cortex and hippocampus. | 2002 Jul |
3 |
| 43 |
12107056 | Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2. | 2002 Aug |
2 |
| 44 |
12221013 | Changes in phosphodiesterase activity in the developing rat submandibular gland. | 2002 Aug |
3 |
| 45 |
12358727 | Kinetics of nitric oxide-cyclic GMP signalling in CNS cells and its possible regulation by cyclic GMP. | 2002 Oct |
3 |
| 46 |
11150485 | The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat. | 2001 Jan 12 |
3 |
| 47 |
11181844 | Nerve growth factor inhibits PC12 cell PDE 2 phosphodiesterase activity and increases PDE 2 binding to phosphoproteins. | 2001 Feb |
1 |
| 48 |
11532906 | Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. | 2001 Aug 31 |
1 |
| 49 |
10704943 | Inactivation of atrial natriuretic factor-stimulated cyclic guanosine 3',5'-monophosphate (cGMP) in UMR-106 osteoblast-like cells. | 2000 May 1 |
4 |
| 50 |
10913949 | Role of phosphodiesterase and protein kinase G on nitric oxide-induced inhibition of prolactin release from the rat anterior pituitary. | 2000 Aug |
2 |