eniluracil

dihydropyrimidine dehydrogenase ; Homo sapiens







24 Article(s)
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1 33755421 The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil. 2021 Apr 13 2
2 21344302 Final results of a prematurely discontinued Phase 1/2 study of eniluracil with escalating doses of 5-fluorouracil administered orally in patients with advanced hepatocellular carcinoma. 2011 Oct 2
3 16466986 A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract. 2006 Feb 2
4 12904894 Dihydropyrimidine dehydrogenase (DPD) rapidly regenerates after inactivation by eniluracil (GW776C85) in primary and metastatic colorectal cancer. 2003 Nov 11
5 12006517 Impact of two weekly schedules of oral eniluracil given with fluorouracil and leucovorin on the duration of dihydropyrimidine dehydrogenase inhibition. 2002 May 3
6 12140902 The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil. 2002 1
7 12448660 Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer. 2002 Nov 1
8 11219979 Oral eniluracil/5-FU for advanced colon and breast carcinomas. 2001 Jan 1
9 11283924 Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma. 2001 Apr 1 1
10 11459999 Peripheral neuropathy associated with weekly oral 5-fluorouracil, leucovorin and eniluracil. 2001 Jul 3
11 11060767 Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. 2000 Jul 5
12 11081572 Preclinical development of eniluracil: enhancing the therapeutic index and dosing convenience of 5-fluorouracil. 2000 Nov 2
13 11081573 Pharmacology of fluorinated pyrimidines: eniluracil. 2000 Nov 2
14 11081574 Clinical development of eniluracil/fluorouracil: an oral treatment for patients with solid tumors. 2000 Nov 4
15 11106122 Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies. 2000 Oct 2
16 10037177 Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer. 1999 Feb 2
17 10561307 Eniluracil treatment completely inactivates dihydropyrimidine dehydrogenase in colorectal tumors. 1999 Aug 3
18 10595802 Novel oral fluoropyrimidines in the treatment of metastatic colorectal cancer. 1999 Dec 1 2
19 9552051 Phase I clinical and pharmacologic study of eniluracil plus fluorouracil in patients with advanced cancer. 1998 Apr 2
20 9556784 Improving 5-FU with a novel dihydropyrimidine dehydrogenase inactivator. 1998 Mar 2
21 9830627 Clinical development of eniluracil: current status. 1998 Oct 2
22 9264323 Dual modulation of 5-fluorouracil cytotoxicity using folinic acid with a dihydropyrimidine dehydrogenase inhibitor. 1997 Jun 1 1
23 9816071 Dihydropyrimidine dehydrogenase: a tumoral target for fluorouracil modulation. 1995 Sep 1
24 1544906 Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil. 1992 Mar 15 5