| 1 |
34863048 | Endogenous metabolic markers for predicting the activity of dihydropyrimidine dehydrogenase. | 2022 May |
1 |
| 2 |
33755421 | The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil. | 2021 Apr 13 |
1 |
| 3 |
34717904 | Mammalian dihydropyrimidine dehydrogenase. | 2021 Dec 15 |
4 |
| 4 |
34901834 | A narrative review of genetic factors affecting fluoropyrimidine toxicity. | 2021 Dec |
1 |
| 5 |
32830091 | Significance of expression of pyrimidine metabolizing genes in colon cancer. | 2020 Sep |
1 |
| 6 |
31482228 | Dihydropyrimidine dehydrogenase in the metabolism of the anticancer drugs. | 2019 Dec |
1 |
| 7 |
29515256 | Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer. | 2018 Apr |
1 |
| 8 |
29526981 | [Dihydropyrimidine dehydrogenase deficiency causes severe adverse effects of capecitabine]. | 2018 |
1 |
| 9 |
29769267 | Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals. | 2018 Aug |
2 |
| 10 |
31149530 | Severe adverse events due to dihydropyrimidine dehydrogenase deficiency in a Japanese patient with colon cancer taking capecitabine: a case report. | 2018 Oct |
2 |
| 11 |
28835573 | Higher Tissue Levels of Thymidylate Synthase Determined by ELISA Are Associated with Poor Prognosis of Patients with Lung Cancer. | 2017 Aug |
1 |
| 12 |
28851987 | P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting. | 2017 Aug 29 |
3 |
| 13 |
26609109 | Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression. | 2016 Feb |
4 |
| 14 |
26804652 | Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene. | 2016 Apr |
2 |
| 15 |
24943064 | Determination of DPYD enzyme activity in Korean population. | 2015 Apr |
1 |
| 16 |
25112781 | Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer. | 2015 Jul |
2 |
| 17 |
25117664 | Genetic variation in dihydropyrimidine dehydrogenase (DPYD) gene in a healthy adult Indian population. | 2015 Jan |
2 |
| 18 |
25066213 | Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk. | 2014 Oct |
2 |
| 19 |
23603345 | Dihydropyrimidine dehydrogenase gene (DPYD) polymorphism among Caucasian and non-Caucasian patients with 5-FU- and capecitabine-related toxicity using full sequencing of DPYD. | 2013 Mar-Apr |
1 |
| 20 |
23942539 | Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients. | 2013 Oct |
1 |
| 21 |
23960437 | Screening of dihydropyrimidine dehydrogenase genetic variants by direct sequencing in different ethnic groups. | 2013 Aug |
1 |
| 22 |
24101147 | (13)C-uracil breath test to predict 5-fluorouracil toxicity in gastrointestinal cancer patients. | 2013 Dec |
1 |
| 23 |
21114665 | Hemizygous deletions on chromosome 1p21.3 involving the DPYD gene in individuals with autism spectrum disorder. | 2011 Nov |
1 |
| 24 |
21668582 | Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. | 2011 Sep |
1 |
| 25 |
21791367 | Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, orotate phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration: a pilot study. | 2011 Sep |
2 |
| 26 |
19822137 | Two cases of 5-fluorouracil toxicity linked with gene variants in the DPYD gene. | 2010 Feb |
1 |
| 27 |
18620897 | The role of dihydropyrimidine dehydrogenase expression in resistance to 5-fluorouracil in head and neck squamous cell carcinoma cells. | 2009 Feb |
1 |
| 28 |
19381049 | [Significance of urinary uracil measurement following administration of DPD inhibitory fluoropyrimidine(DIF)products]. | 2009 Apr |
1 |
| 29 |
19571472 | Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism. | 2009 |
2 |
| 30 |
18937829 | Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy. | 2008 Oct 20 |
1 |
| 31 |
16556484 | FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene (DPYD). | 2007 Feb 8 |
2 |
| 32 |
17611699 | DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. | 2007 Aug |
1 |
| 33 |
16912518 | [Dihydropyrimidine dehydrogenase activity and its genetic aberrations]. | 2006 Aug |
1 |
| 34 |
17065072 | A pivotal role for beta-aminoisobutyric acid and oxidative stress in dihydropyrimidine dehydrogenase deficiency? | 2006 |
3 |
| 35 |
15899693 | Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function. | 2005 Apr |
1 |
| 36 |
17375478 | Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese. | 2005 Jun |
1 |
| 37 |
14705962 | New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid? | 2004 Apr 1 |
1 |
| 38 |
15045945 | [Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography]. | 2004 Mar |
1 |
| 39 |
15628771 | [Significance of tissue thymidine phosphorylase and dihydropyrimidine dehydrogenase activities in ovarian cancer]. | 2004 Dec |
1 |
| 40 |
12527930 | High-throughput genotyping by DHPLC of the dihydropyrimidine dehydrogenase gene implicated in (fluoro)pyrimidine catabolism. | 2003 Feb |
1 |
| 41 |
12851836 | Clinical implications of dihydropyrimidine dehydrogenase (DPD) activity in 5-FU-based chemotherapy: mutations in the DPD gene, and DPD inhibitory fluoropyrimidines. | 2003 Jun |
1 |
| 42 |
12910418 | Dihydropyrimidine dehydrogenase in normal and malignant endometrium: relationship with cell proliferation and thymidine phosphorylase. | 2003 Nov |
1 |
| 43 |
14658877 | The Pacman effect: a supramolecular strategy for controlling the excited-state dynamics of pillared cofacial bisporphyrins. | 2003 Dec 15 |
1 |
| 44 |
11836594 | Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer. | 2002 Mar-Apr |
1 |
| 45 |
11936689 | Measurement of endogenous uracil and dihydrouracil in plasma and urine of normal subjects by liquid chromatography-tandem mass spectrometry. | 2002 Mar 25 |
2 |
| 46 |
12104082 | Development and characterization of a monoclonal antibody with cross-reactivity towards uracil and thymine, and its potential use in screening patients treated with 5-fluorouracil for possible risks. | 2002 Aug |
2 |
| 47 |
11668512 | Thymidine phosphorylase and dihydropyrimidine dehydrogenase protein expression in colorectal cancer. | 2001 Oct 15 |
3 |
| 48 |
10777676 | Cloning and initial characterization of the human DPYD gene promoter. | 2000 Apr 29 |
3 |
| 49 |
10778957 | Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. | 2000 Apr |
2 |
| 50 |
10779372 | Mechanism-based inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil in the presence of NADPH. | 2000 May |
1 |