N-Acetylneuraminic Acid

CD33 molecule ; Homo sapiens







43 Article(s)
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1 35408990 CD33 rs2455069 SNP: Correlation with Alzheimer's Disease and Hypothesis of Functional Role. 2022 Mar 26 6
2 35452678 Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease. 2022 Apr 20 2
3 32845322 Human-specific microglial Siglec-11 transcript variant has the potential to affect polysialic acid-mediated brain functions at a distance. 2021 Apr 1 1
4 33539598 Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype. 2021 Jun 1
5 33708213 The Role of Siglec-G on Immune Cells in Sepsis. 2021 1
6 33720433 CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer's disease-protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion. 2021 Jul 2
7 32556248 Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins. 2020 Jul 1 2
8 30953118 Expression profiling of immune inhibitory Siglecs and their ligands in patients with glioma. 2019 Jun 1
9 31369984 Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis. 2019 Sep 27 4
10 31387789 A glycal-based photoaffinity probe that enriches sialic acid binding proteins. 2019 Sep 15 1
11 31411573 Detection of CD33 expression on monocyte surface is influenced by phagocytosis and temperature. 2019 Sep 1
12 30130255 Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells. 2018 Nov 1 1
13 28194834 Steering Siglec-Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry. 2017 Mar 13 2
14 28205451 Sialylation of Porphyromonas gingivalis LPS and its effect on bacterial-host interactions. 2017 Apr 3
15 28325905 Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression. 2017 Mar 21 1
16 28747436 The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool. 2017 Sep 15 1
17 26411873 Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation. 2016 Feb 1
18 25448602 Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex. 2015 Feb 1
19 25846707 Siglec receptors impact mammalian lifespan by modulating oxidative stress. 2015 Apr 7 1
20 24674885 Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia. 2014 Jun 2
21 24921038 Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas. 2014 Jun 1 1
22 25059667 Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33. 2014 Sep 5 3
23 25166301 Gene conversions are frequent but not under positive selection in the Siglec gene families of primates. 2014 Jun 1
24 25320078 Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. 2014 Nov 28 1
25 23946390 CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing. 2013 Aug 14 1
26 21278227 Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells. 2011 Jun 1
27 19337729 Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region. 2009 May 1
28 17947393 ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2. 2008 Jan 1
29 18279844 CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease. 2008 Aug 11 1
30 17008544 CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover. 2007 Feb 1 1
31 17138568 SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses. 2007 Feb 9 1
32 16728277 Myeloid precursors and acute myeloid leukemia cells express multiple CD33-related Siglecs. 2006 Jun 2
33 15597323 Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling. 2005 Jan 5
34 15769739 Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. 2005 May 20 1
35 14693915 A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor. 2004 Apr 1
36 15557178 The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. 2004 Dec 1 1
37 12773563 CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. 2003 Jun 8
38 11970770 CD33 as a target for selective ablation of acute myeloid leukemia. 2002 Mar 1
39 11095983 Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene. 2000 Nov 30 1
40 10206955 The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. 1999 Apr 23 2
41 10556798 The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. 1999 Nov 1
42 8702538 A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33. 1996 Aug 2 1
43 7718872 Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. 1995 Apr 15 6