Serine

synuclein alpha ; Homo sapiens







123 Article(s)
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1 34973339 Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties. 2022 Feb 5
2 34984583 Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease? 2022 Feb 1
3 35353605 α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity. 2022 Apr 12 3
4 33157086 Neuronal Bmi-1 is critical for melatonin induced ubiquitination and proteasomal degradation of α-synuclein in experimental Parkinson's disease models. 2021 Aug 15 1
5 33357908 Chitosan nanocarrier for FTY720 enhanced delivery retards Parkinson's disease via PP2A-EzH2 signaling in vitro and ex vivo. 2021 Feb 15 1
6 33361597 Behavioral Deficits and Brain α-Synuclein and Phosphorylated Serine-129 α-Synuclein in Male and Female Mice Overexpressing Human α-Synuclein. 2021 2
7 33428941 Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies. 2021 Jan-Jun 2
8 33538595 Membrane Remodeling and Stimulation of Aggregation Following α-Synuclein Adsorption to Phosphotidylserine Vesicles. 2021 Feb 18 2
9 33556542 In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129. 2021 May 2
10 33579026 Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner. 2021 Feb 10 1
11 34115198 The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy. 2021 Sep 1
12 34613964 Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein. 2021 2
13 34658833 Alterations of Erythrocytic Phosphorylated Alpha-Synuclein in Different Subtypes and Stages of Parkinson's Disease. 2021 1
14 34748321 Orientation of α-Synuclein at Negatively Charged Lipid Vesicles: Linear Dichroism Reveals Time-Dependent Changes in Helix Binding Mode. 2021 Nov 17 2
15 34772466 Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2. 2021 Nov 12 2
16 34827685 The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models. 2021 Nov 12 1
17 32089817 Phosphorylated Alpha-Synuclein in Red Blood Cells as a Potential Diagnostic Biomarker for Multiple System Atrophy: A Pilot Study. 2020 1
18 32156613 Generation of monoclonal antibodies against phosphorylated α-Synuclein at serine 129: Research tools for synucleinopathies. 2020 Apr 23 4
19 32291284 Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation. 2020 May 22 4
20 32324926 Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases. 2020 Jul 1
21 32393581 Chronic α-Synuclein Accumulation in Rat Hippocampus Induces Lewy Bodies Formation and Specific Cognitive Impairments. 2020 May/Jun 1
22 32557839 Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson's Disease With Orthostatic Hypotension. 2020 Sep 1
23 32568772 Role of alpha-synuclein phosphorylation at Serine 129 in methamphetamine-induced neurotoxicity in vitro and in vivo. 2020 Aug 5 1
24 32624505 Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells. 2020 Jun 30 1
25 32630529 Prolyl Endopeptidase-Like Facilitates the α-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF. 2020 Jun 25 2
26 32971383 No enhanced (p-) α-synuclein deposition in gastrointestinal tissue of Parkinson's disease patients. 2020 Nov 1
27 32978333 Withdrawal: Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes. 2020 Sep 25 1
28 33328957 Alpha-Synuclein Accumulation and Its Phosphorylation in the Enteric Nervous System of Patients Without Neurodegeneration: An Explorative Study. 2020 1
29 33380345 Cognitive impact of COVID-19: looking beyond the short term. 2020 Dec 30 1
30 30136097 Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy. 2019 May 2
31 30219847 Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein. 2019 Jan 1 1
32 30472757 Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene. 2019 Feb 1
33 30770596 Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility. 2019 Oct 1
34 31790267 Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils. 2019 Dec 19 2
35 31856920 Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates. 2019 Dec 19 1
36 27875637 AMBRA1, a novel α-synuclein-binding protein, is implicated in the pathogenesis of multiple system atrophy. 2018 Jan 1
37 29725300 Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells. 2018 2
38 30250046 Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study. 2018 Sep 24 2
39 27900791 Robust graft survival and normalized dopaminergic innervation do not obligate recovery in a Parkinson disease patient. 2017 Jan 1
40 28195695 O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding. 2017 Apr 21 1
41 28468843 Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder. 2017 May 30 2
42 28487126 O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein. 2017 Sep 15 3
43 28534083 Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. 2017 Aug 1
44 28619074 Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates. 2017 Jun 16 1
45 28620826 Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein. 2017 Sep 1
46 28969383 A ventral glomerular deficit in Parkinson's disease revealed by whole olfactory bulb reconstruction. 2017 Oct 1 2
47 26719332 Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization. 2016 Feb 26 3
48 26756744 Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders. 2016 1
49 27064513 Influence of 6-Hydroxydopamine Toxicity on α-Synuclein Phosphorylation, Resting Vesicle Expression, and Vesicular Dopamine Release. 2016 Dec 1
50 27240409 Parkinson's Disease: Assay of Phosphorylated α-Synuclein in Skin Biopsy for Early Diagnosis and Association with Melanoma. 2016 May 26 1