| 1 |
33000894 | Role of serine 365 in BRAF V600E sensitivity to RAF inhibition. | 2021 Jul |
1 |
| 2 |
34844526 | Integrated computational approach for in silico design of new purinyl pyridine derivatives as B-Raf kinase inhibitors. | 2021 Nov 29 |
2 |
| 3 |
29753091 | Increase in constitutively active MEK1 species by introduction of MEK1 mutations identified in cancers. | 2019 Jan |
2 |
| 4 |
29545175 | RUVBL1, a novel C-RAF-binding protein, activates the RAF/MEK/ERK pathway to promote lung cancer tumorigenesis. | 2018 Apr 15 |
2 |
| 5 |
30030377 | The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho-Ser-621 in the C terminus of CRAF. | 2018 Sep 14 |
2 |
| 6 |
30154518 | Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics. | 2018 Aug 28 |
1 |
| 7 |
30404005 | BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association. | 2018 Nov 6 |
1 |
| 8 |
26705936 | Tumor associated macrophages provide the survival resistance of tumor cells to hypoxic microenvironmental condition through IL-6 receptor-mediated signals. | 2017 Jan |
1 |
| 9 |
28694330 | Phosphorylation of the C-Raf N Region Promotes Raf Dimerization. | 2017 Oct 1 |
2 |
| 10 |
24658061 | Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer. | 2014 |
1 |
| 11 |
24746704 | Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors. | 2014 May 12 |
1 |
| 12 |
22556409 | The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance. | 2012 Jun 22 |
6 |
| 13 |
21317286 | BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling. | 2011 May 20 |
1 |
| 14 |
20234004 | A loss-of-function screen reveals Ras- and Raf-independent MEK-ERK signaling during Chlamydia trachomatis infection. | 2010 Mar 16 |
1 |
| 15 |
20463977 | Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. | 2010 May 5 |
1 |
| 16 |
17981815 | Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options. | 2008 Feb 1 |
2 |
| 17 |
18316782 | Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase. | 2008 Winter |
2 |
| 18 |
18662673 | Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation. | 2008 Oct 3 |
1 |
| 19 |
17613527 | Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates. | 2007 Sep 7 |
2 |
| 20 |
15069084 | Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. | 2004 Jun 4 |
2 |
| 21 |
15180527 | MEK inhibitors: a therapeutic approach to targeting the Ras-MAP kinase pathway in tumors. | 2004 |
1 |
| 22 |
15358159 | MEK inhibition and phosphorylation of serine 4 on B23 are two coincident events in mitosis. | 2004 Aug 27 |
1 |
| 23 |
15385642 | Raf kinase activation of adenylyl cyclases: isoform-selective regulation. | 2004 Oct |
1 |
| 24 |
12837288 | Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway. | 2003 Jul 15 |
3 |
| 25 |
14530258 | Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation. | 2003 Dec 19 |
2 |
| 26 |
11733498 | Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. | 2002 Feb 8 |
3 |
| 27 |
12048182 | Regulation of Raf-Akt Cross-talk. | 2002 Aug 23 |
1 |
| 28 |
12244094 | Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1. | 2002 Nov 22 |
3 |
| 29 |
11274179 | Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation. | 2001 Jul 6 |
1 |
| 30 |
11443134 | Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. | 2001 Sep 7 |
3 |
| 31 |
10645003 | Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-gamma is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1. | 2000 Jan 13 |
1 |
| 32 |
10576742 | Phosphorylation and regulation of Raf by Akt (protein kinase B). | 1999 Nov 26 |
1 |
| 33 |
10597268 | Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. | 1999 Nov 18 |
2 |
| 34 |
9665134 | A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. | 1998 Jul 2 |
6 |
| 35 |
9322921 | Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway. | 1997 Oct |
1 |
| 36 |
9322943 | Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation. | 1997 Oct |
1 |
| 37 |
8649803 | Activation of Mil/Raf protein kinases in mitotic cells. | 1996 Mar 7 |
1 |
| 38 |
7534298 | The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cells. | 1995 Mar 10 |
1 |
| 39 |
8035810 | Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues. | 1994 Aug |
1 |
| 40 |
3274084 | Structural analysis of normal and transforming mil(raf) proteins: effect of 5'-truncation on phosphorylation in vivo or in vitro. | 1988 Oct |
1 |