| 1 |
30834235 | Chk1 Inhibition Restores Inotuzumab Ozogamicin Citotoxicity in CD22-Positive Cells Expressing Mutant p53. | 2019 |
1 |
| 2 |
23537372 | UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines. | 2013 Mar 28 |
1 |
| 3 |
22905155 | p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription. | 2012 |
2 |
| 4 |
21889927 | M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe. | 2011 Dec 1 |
1 |
| 5 |
22101337 | Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent. | 2011 Dec 1 |
1 |
| 6 |
18642443 | Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells. | 2008 Jul 1 |
1 |
| 7 |
17900801 | AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation. | 2007 Nov 8 |
1 |
| 8 |
18088187 | p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest. | 2007 Dec |
1 |
| 9 |
15642191 | [Abrogation effect of UCN-01 on radiation-induced G2 phase arrest of tumor cells and its mechanism]. | 2005 Jan |
1 |
| 10 |
15782134 | Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints. | 2005 May 26 |
1 |
| 11 |
14743382 | Cell cycle checkpoints and their impact on anticancer therapeutic strategies. | 2004 Feb 1 |
1 |
| 12 |
15466201 | Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event. | 2004 Oct 1 |
1 |
| 13 |
15724841 | Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01. | 2004 Oct |
4 |
| 14 |
12517773 | The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. | 2003 Jan 1 |
2 |
| 15 |
11953432 | Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation. | 2002 Jul 19 |
1 |
| 16 |
12071807 | 7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines. | 2002 Jul |
1 |
| 17 |
10663644 | Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest. | 2000 |
2 |
| 18 |
10699952 | UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation. | 2000 Mar 1 |
4 |
| 19 |
11029511 | UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells. | 2000 Nov |
1 |
| 20 |
9307289 | Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. | 1997 Sep 15 |
1 |
| 21 |
9395460 | Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells. | 1997 Dec 12 |
2 |
| 22 |
9815601 | UCN-01 in ovary cancer cells: effective as a single agent and in combination with cis-diamminedichloroplatinum(II)independent of p53 status. | 1997 Nov |
1 |