MK-8776

tumor protein p53 ; Homo sapiens







7 Article(s)
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1 30837643 Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo. 2019 Mar 5 2
2 30103170 Metronomic oral doxorubicin in combination of Chk1 inhibitor MK-8776 for p53-deficient breast cancer treatment. 2018 Nov 5
3 28888100 Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells. 2017 Oct 1
4 27556692 Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells. 2016 Sep 20 2
5 27690219 MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. 2016 Nov 1 1
6 23536721 The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair. 2013 Jun 1
7 24113549 CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells. 2013 Dec 1