Lenalidomide

tumor protein p53 ; Homo sapiens







27 Article(s)
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1 35512188 Lenalidomide promotes the development of TP53-mutated therapy-related myeloid neoplasms. 2022 May 5 5
2 32251398 Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome. 2020 May 1
3 32323826 Antitumor effect of lenalidomide in malignant glioma cell lines. 2020 May 1
4 30598450 Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response. 2019 Jan 15 1
5 30608891 Lenalidomide for the treatment of mantle cell lymphoma. 2019 Apr 1
6 29269520 Emergence and evolution of TP53 mutations are key features of disease progression in myelodysplastic patients with lower-risk del(5q) treated with lenalidomide. 2018 Apr 1
7 30097406 SOHO State of the Art and Next Questions: Management of Myelodysplastic Syndromes With Deletion 5q. 2018 Oct 1
8 27884971 Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations. 2017 Mar 1
9 27967292 The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications. 2017 Aug 1
10 29296763 A case of lenalidomide-dependent myelodysplastic syndrome. 2017 Jul 11 1
11 26967821 Lenalidomide treatment and prognostic markers in relapsed or refractory chronic lymphocytic leukemia: data from the prospective, multicenter phase-II CLL-009 trial. 2016 Mar 11 1
12 27133825 Prevalence, clonal dynamics and clinical impact of TP53 mutations in patients with myelodysplastic syndrome with isolated deletion (5q) treated with lenalidomide: results from a prospective multicenter study of the german MDS study group (GMDS). 2016 Sep 1
13 26075044 Recent Advances in the 5q- Syndrome. 2015 1
14 24627193 Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide. 2014 May 1
15 24682512 p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q). 2014 Jun 1
16 24990888 Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53. 2014 Sep 4 2
17 25295231 PP2A: The Achilles Heal in MDS with 5q Deletion. 2014 1
18 22525275 Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion. 2013 Feb 28 3
19 23614682 Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations. 2013 Jul 2
20 24043769 TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients. 2013 Oct 1 2
21 21968939 Lenalidomide enhances the anti-prostate cancer activity of docetaxel in vitro and in vivo. 2012 Jun 1 1
22 22109882 The immunomodulatory drug lenalidomide restores a vitamin D sensitive phenotype to the vitamin D resistant breast cancer cell line MDA-MB-231 through inhibition of BCL-2: potential for breast cancer therapeutics. 2012 Feb 1
23 22261445 p53 nuclear expression correlates with hemizygous TP53 deletion and predicts an adverse outcome for patients with relapsed/refractory multiple myeloma treated with lenalidomide. 2012 Feb 4
24 22933333 Incidence of 17p deletions and TP53 mutation in myelodysplastic syndrome and acute myeloid leukemia with 5q deletion. 2012 Dec 1
25 23556117 Efficacy and safety of lenalidomide in patients with myelodysplastic syndrome with chromosome 5q deletion. 2012 Apr 1
26 21321360 Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications. 2011 Apr 28 1
27 19797731 Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression. 2009 Dec 1