Histidine

tumor protein p53 ; Homo sapiens







53 Article(s)
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1 35487360 Critical target identification and human health risk ranking of metal ions based on mechanism-driven modeling. 2022 Aug 1
2 30802707 Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2-p53 interaction. 2019 May 1
3 30140002 Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246. 2018 Aug 23 1
4 28710679 New Phage Display-Isolated Heptapeptide Recognizing the Regulatory Carboxy-Terminal Domain of Human Tumour Protein p53. 2017 Oct 1
5 28874603 Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins. 2017 Sep 5 2
6 27479485 Chloroacetamide-Linked Nucleotides and DNA for Cross-Linking with Peptides and Proteins. 2016 Sep 21 2
7 27601274 G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53. 2016 Sep 7 4
8 27735058 Variation of free-energy landscape of the p53 C-terminal domain induced by acetylation: Enhanced conformational sampling. 2016 Dec 5 1
9 26345853 Genome-scale meta-analysis of DNA methylation during progression of lung adenocarcinoma. 2015 Aug 7 1
10 25215298 Involvement of p53 mutation and mismatch repair proteins dysregulation in NNK-induced malignant transformation of human bronchial epithelial cells. 2014 1
11 25221773 In silico study of fragile histidine triad interaction domains with MDM2 and p53. 2014 3
12 23863845 Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. 2013 Oct 2
13 20193843 Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation. 2010 Mar 1
14 18707164 Quantum mechanical studies of residue-specific hydrophobic interactions in p53-MDM2 binding. 2008 Sep 11 1
15 18717684 Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas. 2008 Dec 1
16 19127115 Genetic counseling can influence the course of a suspected familial cancer syndrome patient: from a case of Li-Fraumeni like syndrome with a germline mutation in the TP53 gene. 2008 Dec 1
17 16251206 Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites. 2006 Mar 1
18 15942101 A patient with TP53 germline mutation developed Bowen's disease and myelodysplastic syndrome with myelofibrosis after chemotherapy against ovarian cancer. 2005 May 1
19 16059916 Exposure to ELF magnetic field tuned to Zn inhibits growth of cancer cells. 2005 Dec 5
20 15358233 Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen. 2004 Aug 13 1
21 12802925 A novel c-kit positive biphenotypic acute leukemia cell line, TMBL-1, carrying a p53 point mutation. 2003 May 1
22 14595027 Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide. 2003 Nov 11 1
23 11782367 Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. 2002 Jan 1 1
24 11948395 Characterization of the p53-rescue drug CP-31398 in vitro and in living cells. 2002 Mar 28 1
25 12177781 Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma. 2002 Aug 12 1
26 12200603 p53 Germline mutation in a patient with Li-Fraumeni Syndrome and three metachronous malignancies. 2002 Aug 1
27 11273008 Second primary glioblastoma. 2001 Feb 1
28 11447225 Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. 2001 Sep 28 2
29 11527429 Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka). 2001 Sep 7 1
30 11563689 Common conformational effects of p53 mutations. 2001 Feb 1
31 21340840 p53 Adenovirus as Gene Therapy for Ovarian Cancer. 2001 1
32 10747932 Genetic analysis of a potential zinc-binding domain of the adenovirus E4 34k protein. 2000 May 19 1
33 11042688 Differences in mutant p53 protein stability and functional activity in teniposide-sensitive and -resistant human leukemic CEM cells. 2000 Oct 12 1
34 11097743 TNF-alpha induced p21(WAF1) but not Bax in colon cancer cells WiDr with mutated p53: important role of protein stabilization. 2000 Dec 4
35 10531375 Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells. 1999 Oct 29 1
36 9472015 High mobility group protein-1 (HMG-1) is a unique activator of p53. 1998 Feb 15 2
37 9581865 High affinity MAR-DNA binding is a common property of murine and human mutant p53. 1998 Jun 1 2
38 9605749 Wild-type and mutant forms of p53 activate human topoisomerase I: a possible mechanism for gain of function in mutants. 1998 May 15 3
39 9790785 Establishment and characterization of a new HPV-negative squamous cell carcinoma cell line (Yumoto) from the human uterine cervix. 1998 Sep 1
40 8985102 Transformation of normal human fibroblasts into immortalized cells with the mutant p53 gene and X-rays. 1997 Jan 6 1
41 9154814 neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice. 1997 Jun 2
42 8649776 The 273rd codon mutants of p53 show growth modulation activities not correlated with p53-specific transactivation activity. 1996 Jun 6 1
43 8665492 Studies of the p53 gene mutation in Saudi non-Hodgkin's lymphoma. 1996 Jul 12 1
44 8756655 A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. 1996 Sep 1
45 8810317 Regulation of mutant p53 temperature-sensitive DNA binding. 1996 Oct 11 2
46 7594817 Accumulation of mutant p53 and hsp72 by heat treatment, and their association in a human glioblastoma cell line. 1995 Sep-Oct 1
47 7627952 Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53. 1995 Aug 15 1
48 7705936 Transfected mutant p53 gene increases X-ray-induced cell killing and mutation in human fibroblasts immortalized with 4-nitroquinoline 1-oxide but does not induce neoplastic transformation of the cells. 1995 Mar 29 1
49 7847818 Mutant p53 proteins behave in a dominant, negative fashion in vivo. 1994 Sep-Oct 3
50 7937752 Conformational effects of environmentally induced, cancer-related mutations in the p53 protein. 1994 Sep 27 1