Valproic Acid

tumor protein p53 ; Homo sapiens







22 Article(s)
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1 33576217 Effect of Valproic Acid on the Class I Histone Deacetylase 1, 2 and 3, Tumor Suppressor Genes p21WAF1/CIP1 and p53, and Intrinsic Mitochondrial Apoptotic Pathway, Pro- (Bax, Bak, and Bim) and anti- (Bcl-2, Bcl-xL, and Mcl-1) Apoptotic Genes Expression, Cell Viability, and Apoptosis Induction in Hepatocellular Carcinoma HepG2 Cell Line. 2021 Feb 1 3
2 34660288 Valproic Acid Enhanced Temozolomide-Induced Anticancer Activity in Human Glioma Through the p53-PUMA Apoptosis Pathway. 2021 4
3 32738659 Effective treatment of drug-resistant lung cancer via a nanogel capable of reactivating cisplatin and enhancing early apoptosis. 2020 Oct 2
4 29785653 Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma. 2018 Aug 1
5 28055238 Valproic Acid Increases Histone Acetylation and Alters Gene Expression in the Donor Cells But Does Not Improve the In Vitro Developmental Competence of Buffalo (Bubalus bubalis) Embryos Produced by Hand-Made Cloning. 2017 Feb 1
6 28160167 Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells. 2017 Apr 1
7 28328238 Valproic Acid Induces Decreased Expression of H19 Promoting Cell Apoptosis in A549 Cells. 2017 Jun 1
8 28454438 CHK2 is involved in the p53-independent radiosensitizing effects of valproic acid. 2017 Apr 3
9 28802253 The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer. 2017 Dec 1
10 29212503 Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53. 2017 Dec 6 1
11 30603472 Valproic Acid Modulates the Multipotency in Periodontal Ligament Stem Cells via p53-Mediated Cell Cycle. 2017 Apr 1
12 26812881 Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia. 2016 Feb 16 1
13 22064349 Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. 2012 May 5
14 22642109 Valproic acid decreases the reparation capacity of irradiated MOLT-4 cells. 2012 Jan-Feb 1
15 21120637 A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. 2011 Jun 2
16 21303901 Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis. 2011 Apr 1
17 21519790 Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. 2011 Jul 2
18 21562496 Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation. 2011 May 12 1
19 20025549 HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells. 2009 Dec 2
20 17324262 The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study. 2007 Feb 26 3
21 17341630 Effect of valproic acid, a histone deacetylase inhibitor, on cell death and molecular changes caused by low-dose irradiation. 2006 Dec 1
22 16373706 Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. 2005 Dec 1