| 1 |
30838710 | Insulin promotes invasion and migration of KRASG12D mutant HPNE cells by upregulating MMP-2 gelatinolytic activity via ERK- and PI3K-dependent signalling. | 2019 May |
1 |
| 2 |
28535663 | Up-Regulation of RANK Expression via ERK1/2 by Insulin Contributes to the Enhancement of Osteoclast Differentiation. | 2017 May 31 |
2 |
| 3 |
25667991 | Amyloid β oligomer-induced ERK1/2-dependent serine 636/639 phosphorylation of insulin receptor substrate-1 impairs insulin signaling and glycogen storage in human astrocytes. | 2015 Apr 25 |
1 |
| 4 |
26137438 | A major role of insulin in promoting obesity-associated adipose tissue inflammation. | 2015 Jul |
1 |
| 5 |
26266487 | The Interplay of Akt and ERK in Aβ Toxicity and Insulin-Mediated Protection in Primary Hippocampal Cell Culture. | 2015 Nov |
1 |
| 6 |
24247826 | LIM kinase 1 is required for insulin‑dependent cell growth of osteosarcoma cell lines. | 2014 Jan |
2 |
| 7 |
25124623 | Insulin promotes proliferation and migration of breast cancer cells through the extracellular regulated kinase pathway. | 2014 |
1 |
| 8 |
25239597 | Insulin is involved in transcriptional regulation of NKCC and the CFTR Cl(-) channel through PI3K activation and ERK inactivation in renal epithelial cells. | 2014 Nov |
2 |
| 9 |
23564383 | Insulin induces human acyl-coenzyme A: cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer-binding protein α. | 2013 Sep |
1 |
| 10 |
22459351 | Insulin promotes proliferation, survival, and invasion in endometrial carcinoma by activating the MEK/ERK pathway. | 2012 Sep 28 |
2 |
| 11 |
23027183 | Insulin upregulates the expression of zinc finger and BTB domain-containing 7A in HepG2 cells. | 2012 Dec |
2 |
| 12 |
23217386 | MEK1 and MEK2 differentially regulate human insulin- and insulin glargine-induced human bladder cancer T24 cell proliferation. | 2012 Dec |
2 |
| 13 |
21325048 | The identification of raptor as a substrate for p44/42 MAPK. | 2011 Apr |
2 |
| 14 |
21325398 | Insulin-induced oxidative stress up-regulates heme oxygenase-1 via diverse signaling cascades in the C2 skeletal myoblast cell line. | 2011 Apr |
1 |
| 15 |
21854819 | Insulin-induced neurite-like process outgrowth: acceleration of tau protein synthesis via a phosphoinositide 3-kinase~mammalian target of rapamycin pathway. | 2011 Nov |
1 |
| 16 |
21946084 | Insulin deficiency induces abnormal increase in intestinal disaccharidase activities and expression under diabetic states, evidences from in vivo and in vitro study. | 2011 Dec 15 |
1 |
| 17 |
25961241 | Crosstalk with insulin and dependence on PI3K/Akt/mTOR rather than MAPK pathways in upregulation of basal growth following long-term oestrogen deprivation in three human breast cancer cell lines. | 2011 Mar 1 |
1 |
| 18 |
20517899 | Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells. | 2010 Jun |
1 |
| 19 |
19223652 | Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose. | 2009 May |
1 |
| 20 |
18789871 | Insulin induces monocytic CXCL8 secretion by the mitogenic signalling pathway. | 2008 Oct |
1 |
| 21 |
17093923 | Mitofusin 2 (Mfn2): a key player in insulin-dependent myogenesis in vitro. | 2007 Mar |
3 |
| 22 |
17234168 | Insulin augments matrix metalloproteinase-9 expression in monocytes. | 2007 Mar 1 |
3 |
| 23 |
17267401 | Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes. | 2007 Mar 30 |
1 |
| 24 |
17275785 | Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells. | 2007 Mar 23 |
1 |
| 25 |
17370312 | PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor. | 2007 Aug 15 |
2 |
| 26 |
16506055 | Insulin activates hypoxia-inducible factor-1alpha in human and rat vascular smooth muscle cells via phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways: impairment in insulin resistance owing to defects in insulin signalling. | 2006 May |
1 |
| 27 |
17068290 | C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, phosphatidylinositol 3-kinase, and extracellular signal-regulated kinase 1/2. | 2006 Nov 24 |
1 |
| 28 |
17068339 | Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2. | 2006 Dec 22 |
1 |
| 29 |
15624099 | C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells. | 2005 Jan |
1 |
| 30 |
15701678 | Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. | 2005 Jul |
1 |
| 31 |
15739119 | A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells. | 2005 Mar |
1 |
| 32 |
15922332 | Insulin and IGF-1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells. | 2005 Jun 6 |
1 |
| 33 |
16168963 | Contrasting effects of insulin and cellular differentiation on expression of the novel insulin receptor substrate APS in skeletal muscle. | 2005 Nov 1 |
1 |
| 34 |
15069082 | ERK1/2 mediates insulin stimulation of Na(+),K(+)-ATPase by phosphorylation of the alpha-subunit in human skeletal muscle cells. | 2004 Jun 11 |
1 |
| 35 |
15084344 | Cross-talk between the estrogen receptor-, protein kinase A-, and mitogen-activated protein kinase-mediated signaling pathways in the regulation of lactotroph proliferation in primary culture. | 2004 Feb |
1 |
| 36 |
15111768 | Naringenin inhibits glucose uptake in MCF-7 breast cancer cells: a mechanism for impaired cellular proliferation. | 2004 May |
1 |
| 37 |
15172888 | MEK inhibitors impair insulin-stimulated glucose uptake in 3T3-L1 adipocytes. | 2004 Oct |
1 |
| 38 |
15187085 | Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes. | 2004 Aug 13 |
2 |
| 39 |
15473891 | Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance. | 2004 Oct |
1 |
| 40 |
14514641 | Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways. | 2003 Oct |
1 |
| 41 |
14596677 | Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway. | 2003 Nov |
1 |
| 42 |
12167719 | Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. | 2002 Sep |
1 |
| 43 |
12393186 | Multiple signalling pathways mediate insulin-stimulated gene expression in 3T3-L1 adipocytes. | 2002 Oct 11 |
2 |
| 44 |
11160134 | Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. | 2001 Jan |
1 |
| 45 |
11231341 | Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells. | 2001 Mar |
1 |
| 46 |
11313952 | Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. | 2001 Jan 11 |
1 |
| 47 |
11443108 | Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway. | 2001 Aug 31 |
2 |
| 48 |
11594774 | Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells. | 2001 Oct 19 |
1 |
| 49 |
11716532 | Phosphatidylinositol 3-kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene expression by insulin. | 2001 Dec 10 |
1 |
| 50 |
11039477 | Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression. | 2000 Oct |
2 |