Clozapine

dopamine receptor D2 ; Homo sapiens







48 Article(s)
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1 35435461 Changes in corticostriatal connectivity and striatal tissue iron associated with efficacy of clozapine for treatment‑resistant schizophrenia. 2022 Apr 18 1
2 32790988 [Pharmacogenetic aspects of the dopaminergic system in clozapine pharmacodynamics]. 2020 1
3 30670597 The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface. 2019 Apr 5 1
4 31214037 Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor. 2019 1
5 29413518 Unique Effects of Clozapine: A Pharmacological Perspective. 2018 1
6 29156812 Correlation of DRD2 mRNA expression levels with deficit syndrome severity in chronic schizophrenia patients receiving clozapine treatment. 2017 Oct 17 2
7 26666695 Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk variant with clozapine response. 2016 1
8 27491852 The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics. 2016 Sep 1
9 25979645 Clozapine reconstructed: Haloperidol's ability to reduce alcohol intake in the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan. 2015 Jul 1 1
10 24360486 Clozapine administered once versus twice daily: does it make a difference? 2014 Feb 1
11 24488407 α2-Adrenoceptors are targets for antipsychotic drugs. 2014 Mar 1
12 22243698 Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation. 2012 Feb 23 2
13 21496455 Effect of clozapine on the dimerization of serotonin 5-HT(2A) receptor and its genetic variant 5-HT(2A)H425Y with dopamine D(2) receptor. 2011 Jun 1 1
14 21619888 Raclopride lessens the ability of clozapine to suppress alcohol drinking in Syrian golden hamsters. 2011 Sep 1
15 18325493 Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics. 2008 Apr 28 1
16 17242588 EPS profiles: the atypical antipsychotics are not all the same. 2007 Jan 1
17 16040180 Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations. 2006 Jan 5
18 16278074 Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment. 2006 May 1
19 16918396 Pharmacological profile of antipsychotics at monoamine receptors: atypicality beyond 5-HT2A receptor blockade. 2006 Aug 1
20 15694653 Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor. 2005 Feb 1
21 15830237 Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations. 2005 Aug 2
22 16119757 Role of radiology in psychiatry: a review. 2005 May 1
23 15286066 Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2*A1 allele. 2004 Aug 1
24 12876543 [Schizophrenia and addiction: An evaluation of the self-medication hypothesis]. 2003 May-Jun 1
25 12880845 Analysis of D2 dopamine receptor occupancy with quantitative SPET using the high-affinity ligand [123I]epidepride: resolving conflicting findings. 2003 Jul 1
26 11862380 Clozapine can induce high dopamine D(2) receptor occupancy in vivo. 2002 Feb 2
27 11873706 Atypical antipsychotics: mechanism of action. 2002 Feb 1
28 12057028 Saturation of striatal D(2) dopamine receptors by clozapine. 2002 Mar 4
29 12769622 Treatment of schizophrenia and comorbid substance use disorder. 2002 Apr 1
30 11156818 Increased dopamine d(2) receptor occupancy and elevated prolactin level associated with addition of haloperidol to clozapine. 2001 Feb 1
31 15328472 Augmentation strategies in the treatment of schizophrenia. 2001 Nov 1
32 9822897 Clozapine antagonizes the induction of striatal Fos expression by typical neuroleptics. 1998 Oct 9 1
33 9015795 Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. 1997 Feb 1
34 9337781 D2 dopamine receptor occupancy: a crossover comparison of risperidone with clozapine therapy in schizophrenic patients. 1997 Oct 1
35 9353791 Behavioral effects of clozapine and dopamine receptor subtypes. 1997 Sep 1
36 8942453 Individual variation in D2 dopamine receptor occupancy in clozapine-treated patients. 1996 Dec 1
37 7542051 Effect of clozapine and risperidone on 5-HT2 and D2-dopamine receptor binding in the post-mortem human brain. An autoradiographic study. 1995 Mar 2
38 7622344 Recent developments in PET scan imaging of neuroreceptors in schizophrenia. 1995 1
39 7737323 Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor. 1995 Feb 6 1
40 8102973 Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. 1993 Jun 4 1
41 1349574 The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. 1992 May 1
42 1352677 Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. 1992 Jul 1
43 1358125 The importance of serotonin-dopamine interactions in the action of clozapine. 1992 May 1
44 1388021 The current status of PET scanning with respect to schizophrenia. 1992 Aug 1
45 1837996 Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol. 1991 2
46 1695408 PET imaging of dopamine receptors in human basal ganglia: relevance to mental illness. 1990 Jul 1
47 2149339 The interaction of clozapine with dopamine D1 versus dopamine D2 receptor-mediated function: behavioural indices. 1990 Sep 4 1
48 2611521 Behavioural indices of the interaction of clozapine with D1 and D2 dopamine receptors. 1989 Dec 1