Paclitaxel

MCL1 apoptosis regulator, BCL2 family member ; Homo sapiens







32 Article(s)
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1 35633550 The Ethyl Acetate Fraction of Marine Sponge Stylissa carteri Induces Breast Cancer Cell Death via Upregulation of Mcl-1S: an In vitro Study. 2022 May 1 2
2 33824297 Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization. 2021 Apr 6 2
3 34385422 Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer. 2021 Aug 12 7
4 34702806 Correction: Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer. 2021 Oct 26 1
5 31286496 Boosting the apoptotic response of high-grade serous ovarian cancers with CCNE1 amplification to paclitaxel in vitro by targeting APC/C and the pro-survival protein MCL-1. 2020 Feb 15 2
6 31249607 M2I-1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti-mitotic drugs via MCL-1s. 2019 1
7 31815052 Impact of BMI1 expression on the apoptotic effect of paclitaxel in colorectal cancer. 2019 1
8 29899826 Synthetic lethality in CCNE1-amplified high grade serous ovarian cancer through combined inhibition of Polo-like kinase 1 and microtubule dynamics. 2018 May 25 1
9 30563080 Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells. 2018 Dec 5 2
10 28441715 Targeting the Bcl-2 family and P-glycoprotein reverses paclitaxel resistance in human esophageal carcinoma cell line. 2017 Jun 2
11 29137317 Mcl-1 stabilization confers resistance to taxol in human gastric cancer. 2017 Oct 10 7
12 26608370 MPT0B169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and Mcl-1 downregulation. 2016 May 1
13 26769847 Mcl-1 dynamics influence mitotic slippage and death in mitosis. 2016 Feb 2 5
14 27409838 Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer. 2016 Aug 16 6
15 25596561 Mechanism of synergy of BH3 mimetics and paclitaxel in chronic myeloid leukemia cells: Mcl-1 inhibition. 2015 Apr 5 5
16 26036638 MicroRNA-101 inhibits cell progression and increases paclitaxel sensitivity by suppressing MCL-1 expression in human triple-negative breast cancer. 2015 Aug 21 4
17 26503059 IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel. 2015 Oct 27 1
18 24173825 Caffeine inhibits paclitaxel‑induced apoptosis in colorectal cancer cells through the upregulation of Mcl‑1 levels. 2014 Jan 3
19 25122070 Prostate cancer cell response to paclitaxel is affected by abnormally expressed securin PTTG1. 2014 Oct 2
20 25386925 miR-107 activates ATR/Chk1 pathway and suppress cervical cancer invasion by targeting MCL1. 2014 1
21 23577147 Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor. 2013 3
22 23750239 MiR-26a inhibits proliferation and migration of breast cancer through repression of MCL-1. 2013 1
23 23802633 BCL2 and BCLxL are key determinants of resistance to antitubulin chemotherapeutics in melanoma cells. 2013 Aug 1
24 24263099 Bortezomib antagonizes microtubule-interfering drug-induced apoptosis by inhibiting G2/M transition and MCL-1 degradation. 2013 Nov 21 8
25 22847181 Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells. 2012 Nov 1
26 22965228 Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. 2012 Nov 9 2
27 18497956 Down-regulation of Mcl-1 with antisense technology alters the effect of various cytotoxic agents used in treatment of squamous cell carcinoma of the head and neck. 2008 Jun 1
28 18676833 Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. 2008 Aug 1 2
29 14749477 Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. 2004 Jan 1
30 15241487 MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. 2004 Jul 8 2
31 11408609 Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway. 2001 Jul 1
32 11728383 Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism. 2001 Dec 1 1