Sirolimus

MCL1 apoptosis regulator, BCL2 family member ; Homo sapiens







10 Article(s)
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Pub. Year
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1 34331013 Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. 2021 Sep 1
2 32062191 Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells. 2020 May 1
3 28186963 An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells. 2017 Apr 25 1
4 25780003 Expression of Bcl-xL and Mcl-1 in the nonmelanoma skin cancers of renal transplant recipients. 2015 Apr 2
5 26452980 Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation. 2015 Dec 1
6 23741975 Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt/mammalian target of rapamycin and extracellular signal-related kinase signaling pathways. 2014 Mar 1
7 23580240 Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma. 2013 Oct 15 2
8 22190165 Sorafenib, a multikinase inhibitor, is effective in vitro against non-Hodgkin lymphoma and synergizes with the mTOR inhibitor rapamycin. 2012 Mar 1
9 21083937 Rapamycin sensitizes T-ALL cells to dexamethasone-induced apoptosis. 2010 Nov 18 1
10 17010674 Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. 2006 Oct 1