Gangliosides

hexosaminidase subunit alpha ; Homo sapiens







11 Article(s)
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1 28377426 Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease. 2017 Jul 1
2 26401073 Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease. 2015 Sep 21 2
3 19130519 A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. 2009 2
4 16478472 The enzyme-binding region of human GM2-activator protein. 2006 Mar 2
5 15483268 Sequencing, expression, and enzymatic characterization of beta-hexosaminidase in rabbit lacrimal gland and primary cultured acinar cells. 2005 Mar 1
6 12662933 Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease. 2003 Apr 11 2
7 9694901 A Pro504 --> Ser substitution in the beta-subunit of beta-hexosaminidase A inhibits alpha-subunit hydrolysis of GM2 ganglioside, resulting in chronic Sandhoff disease. 1998 Aug 14 1
8 8900233 Molecular analysis of a GM2-activator deficiency in two patients with GM2-gangliosidosis AB variant. 1996 Nov 1
9 1386984 Ganglioside GM2 levels in human melanoma cells: inverse correlation with lysosomal beta-hexosaminidase A activity. 1992 Jul 2
10 1834320 Biochemistry and genetics of Tay-Sachs disease. 1991 Aug 1
11 7376831 Enzyme replacement treatment for Tay-Sachs disease brain cells in culture utilizing concanavalin A-mediated hexosaminidase A uptake: biochemical and morphological evidence of GM2 mobilization. 1980 1