Amino Acids, Essential

solute carrier family 7 member 5 ; Homo sapiens







42 Article(s)
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1 35024147 Proximal-type epithelioid sarcoma in pubic region expressing L-type amino acid transporter 1: A case report. 2022 2
2 35401172 The Nutraceutical Alliin From Garlic Is a Novel Substrate of the Essential Amino Acid Transporter LAT1 (SLC7A5). 2022 1
3 33790117 [Drug Discovery Targeting an Amino Acid Transporter for Diagnosis and Therapy]. 2021 2
4 34503187 Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer. 2021 Aug 30 1
5 34836160 LAT1 and SNAT2 Protein Expression and Membrane Localization of LAT1 Are Not Acutely Altered by Dietary Amino Acids or Resistance Exercise Nor Positively Associated with Leucine or Phenylalanine Incorporation in Human Skeletal Muscle. 2021 Oct 30 2
6 31992742 Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma. 2020 Jan 28 2
7 32093034 Co-Expression Effect of SLC7A5/SLC3A2 to Predict Response to Endocrine Therapy in Oestrogen-Receptor-Positive Breast Cancer. 2020 Feb 19 1
8 32653341 JPH203, a newly developed anti-cancer drug, shows a preincubation inhibitory effect on L-type amino acid transporter 1 function. 2020 Sep 2
9 33028978 ATP modulates SLC7A5 (LAT1) synergistically with cholesterol. 2020 Oct 7 1
10 30784173 Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma. 2019 Apr 2
11 31282475 LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM. 2019 Jul 1 1
12 29150487 Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin. 2018 Jan 4 4
13 29326164 The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). 2018 Feb 23 4
14 29422900 Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses. 2018 1
15 29695141 Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1. 2018 Apr 24 2
16 30048132 Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). 2018 Aug 23 3
17 30103560 The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer. 2018 Aug 12 2
18 30241549 The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model. 2018 Sep 21 3
19 30577601 Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. 2018 Dec 21 2
20 28242177 Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1). 2017 Feb 1
21 28674206 Correction: Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. 2017 Jul 1 2
22 29281830 Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis. 2017 Dec 26 1
23 26682754 Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells. 2016 May 2
24 27302165 Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. 2016 Aug 1 3
25 27486861 LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma. 2016 Dec 1 2
26 27567475 LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells. 2016 Nov 3
27 25979827 Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2. 2015 Jul 2 2
28 25998567 LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. 2015 May 22 1
29 24671056 LAT1 is a central transporter of essential amino acids in human umbilical vein endothelial cells. 2014 3
30 24038088 LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells. 2013 Oct 15 4
31 22373026 Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas. 2012 Feb 28 1
32 22736142 c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells. 2012 Sep 3
33 22007000 Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. 2011 Dec 15 1
34 19890975 Involvement of LAT1 and LAT2 in the high- and low-affinity transport of L-leucine in human retinal pigment epithelial cells (ARPE-19 cells). 2010 May 1
35 18382329 Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells. 2008 Feb 2
36 19035290 Characterization of amino acid transport system L in HTB-41 human salivary gland epidermoid carcinoma cells. 2008 Sep-Oct 1
37 17489360 Gene expression profiles in T24 human bladder carcinoma cells by inhibiting an L-type amino acid transporter, LAT1. 2007 Apr 2
38 16827134 Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells. 2006 May-Jun 1
39 16886618 The RNA interference of amino acid transporter LAT1 inhibits the growth of KB human oral cancer cells. 2006 Jul-Aug 1
40 15863273 Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells. 2005 May 26 1
41 15036654 Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells. 2004 Mar 18 1
42 11557028 Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. 2001 Oct 1 1