| 1 |
22765278 | Effect of peginterferon alfa-2a (40KD) on cytochrome P450 isoenzyme activity. | 2013 Feb |
1 |
| 2 |
11742579 | Interindividual variations in levels and activities of cytochrome P-450 in liver microsomes of Chinese subjects. | 2001 Mar |
1 |
| 3 |
8861658 | Investigation of xenobiotic metabolism by CYP2D6 and CYP2C19: importance of enantioselective analytical methods. | 1996 Mar 29 |
1 |
| 4 |
7935340 | Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. | 1994 Sep |
1 |
| 5 |
8049635 | Lung tumor resection does not affect debrisoquine metabolism. | 1994 Mar |
1 |
| 6 |
8095148 | Molecular heterogeneity of the XbaI defined 44kb allele of the CYP2D locus within the Caucasian population. | 1993 Feb |
1 |
| 7 |
8454228 | [Genetic polymorphism in human drug metabolism]. | 1993 Feb |
2 |
| 8 |
1937350 | Clinical consequences of polymorphic drug oxidation. | 1991 |
1 |
| 9 |
2357863 | Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation. | 1990 Jun |
1 |
| 10 |
2570698 | Clinical significance of the sparteine/debrisoquine oxidation polymorphism. | 1989 |
1 |
| 11 |
2615529 | Variability of 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute leukemia. | 1989 |
1 |
| 12 |
2702801 | Influence of debrisoquin phenotype on the inducibility of propranolol metabolism. | 1989 Apr |
1 |
| 13 |
2775304 | The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man. | 1989 Sep 1 |
1 |
| 14 |
2910639 | Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities. | 1989 Jan |
1 |
| 15 |
2894945 | In vitro evidence against the oxidation of quinidine by the sparteine/debrisoquine monooxygenase of human liver. | 1988 Jan-Feb |
1 |
| 16 |
3067018 | Polymorphic differences in drug metabolism and response. | 1988 Aug |
1 |
| 17 |
3111480 | Irreversible binding and metabolism of propranolol by human liver microsomes--relationship to polymorphic oxidation. | 1987 Jul 15 |
1 |
| 18 |
3472585 | Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22. | 1987 Apr |
2 |
| 19 |
3577206 | Polymorphism of human cytochrome P-450. | 1987 Mar |
1 |
| 20 |
3689440 | Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation. Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency. | 1987 Dec 1 |
2 |
| 21 |
3829342 | Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences. | 1987 Apr |
1 |
| 22 |
2874666 | The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation. | 1986 May |
1 |
| 23 |
3739365 | Oxidation of tricyclic antidepressant drugs, debrisoquine and 7-ethoxyresorufin, by human liver preparations. | 1986 May |
1 |
| 24 |
3745165 | Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol. | 1986 Sep 5 |
1 |
| 25 |
3753522 | Purification of a desmethylimipramine and debrisoquine hydroxylating cytochrome P-450 from human liver. | 1986 Sep 15 |
1 |
| 26 |
3864428 | Normal metabolism of debrisoquine and theophylline in a slow tolbutamide metaboliser. | 1985 Jun |
1 |
| 27 |
3966916 | Genetic polymorphism in drug oxidation: in vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1'-hydroxylase activities. | 1985 Jan 1 |
1 |
| 28 |
4027138 | Phenacetin O-deethylase: an activity of a cytochrome P-450 showing genetic linkage with that catalysing the 4-hydroxylation of debrisoquine? | 1985 Jul |
1 |
| 29 |
6372265 | Human cytochromes P-450. | 1984 Jan-Feb |
1 |
| 30 |
6508804 | Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers. | 1984 Nov 30 |
2 |
| 31 |
6594694 | Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme. | 1984 Dec |
2 |
| 32 |
6697650 | Sparteine oxidation by the human liver: absence of inhibition by mephenytoin. | 1984 Mar |
1 |
| 33 |
6220203 | Substrate specificity of the form of cytochrome P-450 catalyzing the 4-hydroxylation of debrisoquine in man. | 1983 Mar |
2 |
| 34 |
7267701 | Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation. | 1981 |
1 |