Sphingolipids

prosaposin ; Homo sapiens







17 Article(s)
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1 33534127 Prosaposin, a neurotrophic factor, protects neurons against kainic acid-induced neurotoxicity. 2021 Jun 3
2 27913291 A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline. 2017 Feb 1
3 26831127 Clinical, biochemical and molecular characterization of prosaposin deficiency. 2016 Sep 1
4 21835174 Prosaposin sorting is mediated by oligomerization. 2011 Oct 15 1
5 19934382 A stretch of 17 amino acids in the prosaposin C terminus is critical for its binding to sortilin and targeting to lysosomes. 2010 Mar 1
6 20132547 Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion. 2010 Feb 4 1
7 19267410 Prosaposin deficiency and saposin B deficiency (activator-deficient metachromatic leukodystrophy): report on two patients detected by analysis of urinary sphingolipids and carrying novel PSAP gene mutations. 2009 Feb 15 1
8 20021345 Biochemistry and neurobiology of prosaposin: a potential therapeutic neuro-effector. 2009 Jun 1
9 16497666 The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux. 2006 Apr 28 1
10 7857780 Occurrence of prosaposin as a neuronal surface membrane component. 1994 Spring 1
11 8003252 Further evidence that human lysosomal sialidase is not derived from prosaposin. Prosaposin biosynthesis and ganglioside sialidase studies in prosaposin- and sialidase-deficient fibroblast lines. 1994 Jan 1
12 1402395 Saposins: structure, function, distribution, and molecular genetics. 1992 Sep 1
13 1454804 Binding and transport of gangliosides by prosaposin. 1992 Dec 1 1
14 1637339 Additional biochemical findings in a patient and fetal sibling with a genetic defect in the sphingolipid activator protein (SAP) precursor, prosaposin. Evidence for a deficiency in SAP-1 and for a normal lysosomal neuraminidase. 1992 Jul 15 1
15 1958198 Isolation and characterization of prosaposin from human milk. 1991 Nov 27 1
16 2066109 The mechanism for a 33-nucleotide insertion in mRNA causing sphingolipid activator protein (SAP-1)-deficient metachromatic leukodystrophy. 1991 Jun 2
17 3478817 Regional localization of the gene coding for sphingolipid activator protein SAP-1 on human chromosome 10. 1987 Nov 1