Phosphotyrosine

SRC proto-oncogene, non-receptor tyrosine kinase ; Homo sapiens







117 Article(s)
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1 35622130 Comprehensive binary interaction mapping of τ phosphotyrosine sites with SH2 domains in the human genome: Implications for the rational design of self-inhibitory phosphopeptides to target τ hyperphosphorylation signaling in Alzheimer's Disease. 2022 Jun 1
2 34272687 Maternal Ethanol Exposure Acutely Elevates Src Family Kinase Activity in the Fetal Cortex. 2021 Oct 1
3 34367939 c-Src Increases the Sensitivity to TKIs in the EGFR-Mutant Lung Adenocarcinoma. 2021 3
4 30674037 Ethanol Exposure Transiently Elevates but Persistently Inhibits Tyrosine Kinase Activity and Impairs the Growth of the Nascent Apical Dendrite. 2019 Aug 1
5 30823936 A signalling cascade involving receptor-activated phospholipase A2, glycerophosphoinositol 4-phosphate, Shp1 and Src in the activation of cell motility. 2019 Mar 1 2
6 30862675 Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication. 2019 May 3 1
7 28347651 Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. 2017 May 5 5
8 28584191 ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility. 2017 Jul 15 1
9 28768887 Phosphotyrosine signalling and the origin of animal multicellularity. 2017 Aug 16 1
10 28930674 A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. 2017 Sep 19 2
11 26163016 T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells. 2015 Jul 11 1
12 26551075 EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. 2015 Dec 1
13 24121272 SRChing for the substrates of Src. 2014 Sep 11 1
14 24578342 Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12. 2014 May 1 1
15 24632723 SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. 2014 2
16 25074933 Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure. 2014 Sep 12 2
17 24260357 Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer. 2013 1
18 22252131 Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. 2012 Mar 7 2
19 22287273 Src modulates contractile vascular smooth muscle function via regulation of focal adhesions. 2012 Nov 1
20 22499769 Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics. 2012 Aug 1
21 23097045 Src binds cortactin through an SH2 domain cystine-mediated linkage. 2012 Dec 15 2
22 21490433 Trask phosphorylation defines the reverse mode of a phosphotyrosine signaling switch that underlies cell anchorage state. 2011 Apr 15 4
23 22241959 Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032. 2011 Dec 1
24 20698672 Constraining binding hot spots: NMR and molecular dynamics simulations provide a structural explanation for enthalpy-entropy compensation in SH2-ligand binding. 2010 Aug 18 2
25 20943948 c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells. 2010 Dec 1
26 21049007 Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. 2010 Oct 26 1
27 19434004 Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma. 2009 Jun 3
28 19948503 Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. 2009 Nov 16 1
29 18247338 Src-Tyrosine kinases are major agents in mitochondrial tyrosine phosphorylation. 2008 Jun 1 1
30 18342899 Sex-steroid hormones and EGF signalling in breast and prostate cancer cells: targeting the association of Src with steroid receptors. 2008 Oct 2
31 18562702 Increased activity of the human sperm tyrosine kinase SRC by the cAMP-dependent pathway in the presence of calcium. 2008 Oct 2
32 18563927 Global impact of oncogenic Src on a phosphotyrosine proteome. 2008 Aug 1
33 18671371 An enriching phosphotyrosine experience for Src substrates. 2008 Aug 1
34 17189253 Src signaling regulates completion of abscission in cytokinesis through ERK/MAPK activation at the midbody. 2007 Feb 23 1
35 17395980 Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells. 2007 Mar 1
36 17513418 c-Abl tyrosine kinase and inhibition by the cancer drug imatinib (Gleevec/STI-571). 2007 Jun 2
37 16442522 Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. 2006 May 1 1
38 16478788 Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. 2006 Mar 1 1
39 16990796 PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. 2006 Oct 18 1
40 17053785 Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. 2006 Nov 1 1
41 17094785 Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl. 2006 Dec 1
42 15623525 Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family member. 2005 Mar 18 1
43 15634687 The sulfogalactose moiety of sulfoglycosphingolipids serves as a mimic of tyrosine phosphate in many recognition processes. Prediction and demonstration of Src homology 2 domain/sulfogalactose binding. 2005 Apr 1 1
44 15845350 Src kinase regulation by phosphorylation and dephosphorylation. 2005 May 27 6
45 16186108 Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. 2005 Nov 25 1
46 16244766 Increased tyrosine phosphorylation of platelet proteins including pp125(FAK) suggests endogenous activation and aggregation in pulmonary hypertension. 2005 Oct 1
47 14699166 Effective dephosphorylation of Src substrates by SHP-1. 2004 Mar 19 1
48 14759738 Design of tetrapeptide ligands as inhibitors of the Src SH2 domain. 2004 Feb 15 1
49 14963108 Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc. 2004 May 2
50 12584242 Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption. 2003 Mar 15 2