| 1 |
24995339 | Crystal structure of mouse thymidylate synthase in tertiary complex with dUMP and raltitrexed reveals N-terminus architecture and two different active site conformations. | 2014 |
1 |
| 2 |
15539941 | Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice. | 2004 Nov |
2 |
| 3 |
11133837 | Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells. | 2001 Jan |
1 |
| 4 |
10656460 | Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity. | 2000 Jan |
2 |
| 5 |
10996399 | The thymidylate synthase inhibitor ZD1694 potently inhibits murine and human cytomegalovirus replication in quiescent fibroblasts. | 2000 Aug |
1 |
| 6 |
10999757 | Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies. | 2000 Sep |
2 |
| 7 |
11106258 | The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): genetic differences between BALB/c and DBA/2 mice. | 2000 Nov |
3 |
| 8 |
10430100 | Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine. | 1999 Jul |
2 |
| 9 |
9460992 | Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models. | 1998 |
5 |
| 10 |
9613980 | Combined therapeutic efficacy of the thymidylate synthase inhibitor ZD1694 (Tomudex) and the immunotoxin B43(anti-CD19)-PAP in a SCID mouse model of human B-lineage acute lymphoblastic leukemia. | 1998 Feb |
2 |
| 11 |
8911125 | Modulation of [5-125I]iododeoxyuridine incorporation into tumour and normal tissue DNA by methotrexate and thymidylate synthase inhibitors. | 1996 Aug |
1 |
| 12 |
7537518 | Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines. | 1995 May |
2 |
| 13 |
7577036 | ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer. | 1995 Jul-Aug |
4 |
| 14 |
7680860 | The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells. | 1993 Feb 24 |
2 |
| 15 |
1596289 | Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase. | 1992 May 8 |
2 |
| 16 |
1789205 | ICI D1694, an inhibitor of thymidylate synthase for clinical study. | 1991 |
1 |
| 17 |
1913676 | ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. | 1991 Oct 15 |
2 |