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11534765 | In vivo antitumor efficacy of CW252053, a folate-based thymidylate synthase inhibitor. | 2001 Aug |
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10508430 | Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. | 1999 Sep 23 |
1 |
| 3 |
9460992 | Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models. | 1998 |
1 |
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9154971 | Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). | 1997 May 9 |
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7495479 | Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity. | 1995 Oct |
1 |
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7537518 | Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines. | 1995 May |
1 |
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7680860 | The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells. | 1993 Feb 24 |
1 |
| 8 |
8304189 | The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues. | 1993 |
1 |
| 9 |
1596289 | Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase. | 1992 May 8 |
1 |
| 10 |
1613755 | Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues. | 1992 Jun 12 |
1 |
| 11 |
1741766 | The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). | 1991 Oct 24 |
2 |
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1859463 | Inhibition of 2-desamino-2-methyl-10-propagyl-5,8-dideazafolic acid cytotoxicity by 5,10-dideazatetrahydrofolate in L1210 cells with decrease in DNA fragmentation and deoxyadenosine triphosphate pools. | 1991 Jul 15 |
1 |
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2002476 | Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues. | 1991 Mar |
1 |
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2033585 | Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications. | 1991 May |
1 |
| 15 |
2066994 | Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series. | 1991 Jul |
1 |
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2231606 | Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. | 1990 Nov |
1 |
| 17 |
2231607 | Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. | 1990 Nov |
1 |
| 18 |
2231608 | Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series. | 1990 Nov |
1 |
| 19 |
2362285 | Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines. | 1990 Jul |
1 |
| 20 |
2918503 | Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position. | 1989 Mar |
1 |
| 21 |
2930626 | Quinazoline antifolates inhibiting thymidylate synthase: computer modelling of the N10 substituent. | 1989 Mar |
1 |
| 22 |
3599032 | Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. | 1987 Jul |
1 |
| 23 |
3008799 | Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717. | 1986 Mar |
1 |
| 24 |
3712376 | Quinazoline antifolates inhibiting thymidylate synthase: variation of the amino acid. | 1986 Jun |
1 |
| 25 |
3754284 | Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications. | 1986 Apr |
1 |
| 26 |
4045922 | Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent. | 1985 Oct |
1 |