Tolbutamide

cytochrome P450 family 2 subfamily C member 19 ; Homo sapiens







16 Article(s)
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1 33455494 Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19. 2021 Apr 1
2 30992242 Influences of cytochrome b5 expression and its genetic variant on the activity of CYP2C9, CYP2C19 and CYP3A4. 2019 Jun 1
3 28057172 Substrate Specificity of Human Cytochrome P450 (CYP) 2C Subfamily and Effect of Azole Antifungal Agents on CYP2C8. 2016 Oct - Dec 5
4 22886551 Distribution of CYP2C9*13 allele in the Chinese Han and the long-range haplotype containing CYP2C9*13 and CYP2C19*2. 2012 Sep 3
5 16648389 CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone. 2006 Aug 1
6 17010942 Cloning of a cDNA encoding a novel marmoset CYP2C enzyme, expression in yeast cells and characterization of its enzymatic functions. 2006 Dec 15 1
7 12844133 Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9. 2003 Jul 1
8 11875364 Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers. 2002 Mar 2
9 11875365 Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans. 2002 Mar 3
10 10681382 CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes. 2000 Mar 7
11 11038161 Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. 2000 Nov 1
12 9578596 Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. 1998 May 1 6
13 9735164 Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen. 1998 Sep 15 1
14 10022751 An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians. 1998 Apr 2
15 8613906 Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation. 1996 Apr 1
16 8274418 Cortisol metabolism in vitro--III. Inhibition of microsomal 6 beta-hydroxylase and cytosolic 4-ene-reductase. 1993 Dec 1