Cholesterol

3-hydroxy-3-methylglutaryl-CoA reductase ; Rattus norvegicus







244 Article(s)
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1 35420345 Biochemical profiling of lead-intoxicated impaired lipid metabolism and its amelioration using plant-based bioactive compound. 2022 Apr 14 4
2 35559917 Astrocytic PTEN regulates neuropathic pain by facilitating HMGCR-dependent cholesterol biosynthesis. 2022 May 13 3
3 33405196 Chronic Neuroinflammation Induced by Lipopolysaccharide Injection into the Third Ventricle Induces Behavioral Changes. 2021 Jun 1
4 33755739 Role of inflammatory, oxidative, and ER stress signaling in the neuroprotective effect of atorvastatin against doxorubicin-induced cognitive impairment in rats. 2021 Jul 1
5 33934680 Rosuvastatin exposure in female Wistar rats alters uterine contractility and do not show evident (anti)estrogenic effects. 2021 May 3 1
6 34081950 An evolutionarily-conserved promoter allele governs HMG-CoA reductase expression in spontaneously hypertensive rat. 2021 Sep 5
7 31734306 Repeated ethanol exposure influences key enzymes in cholesterol and lipid homeostasis via the AMPK pathway in the rat prefrontal cortex. 2020 Jun 4
8 32125649 Allantoin, a Potential Metabolite That Promotes AMPK Phosphorylation and Suppresses Cholesterol Biosynthesis Via the Mevalonate Pathway and Bloch Pathway. 2020 May 2
9 32395205 The preventive effect of atorvastatin on liver fibrosis in the bile duct ligation rats via antioxidant activity and down-regulation of Rac1 and NOX1. 2020 Jan 1
10 32414094 Dietary Betaine Addition Promotes Hepatic Cholesterol Synthesis, Bile Acid Conversion, and Export in Rats. 2020 May 13 1
11 32504733 Triphenyltin chloride reduces the development of rat adrenal cortex during puberty. 2020 Sep 1
12 32714018 Inhibitory effects of tangeretin and trans-ethyl caffeate on the HMG-CoA reductase activity: Potential agents for reducing cholesterol levels. 2020 Aug 3
13 32807146 Regulation effects of total flavonoids in Morus alba L. on hepatic cholesterol disorders in orotic acid induced NAFLD rats. 2020 Aug 17 1
14 33112815 Prenatal androgen exposure affects ovarian lipid metabolism and steroid biosynthesis in rats. 2020 Dec 1
15 30423027 Effects of Moderate Ethanol Consumption on Lipid Metabolism and Inflammation Through Regulation of Gene Expression in Rats. 2019 Jan 1 1
16 30825513 Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats. 2019 Apr 15 1
17 31278332 Iron overload reduces synthesis and elimination of bile acids in rat liver. 2019 Jul 5 1
18 31599939 Inflammatory Stimuli Trigger Increased Androgen Production and Shifts in Gene Expression in Theca-Interstitial Cells. 2019 Dec 1 1
19 29164519 Atorvastatin Prevents Early Oxidative Events and Modulates Inflammatory Mediators in the Striatum Following Intranasal 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Administration in Rats. 2018 Apr 1
20 29193738 Cooperative role of the glucagon-like peptide-1 receptor and β3-adrenergic-mediated signalling on fat mass reduction through the downregulation of PKA/AKT/AMPK signalling in the adipose tissue and muscle of rats. 2018 Apr 1
21 29340834 Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging. 2018 Apr 1
22 29446047 Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway. 2018 Nov 1
23 29600657 [Effect of leech on lipid metabolism and liver in hyperlipidemia rats]. 2018 Feb 1
24 29718709 Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring. 2018 Oct 2
25 29843042 Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway. 2018 Sep 2
26 30284312 Two weeks of high-fat feeding disturb lipid and cholesterol molecular markers. 2018 Oct 2
27 28397043 Simvastatin prevents lipopolysaccharide-induced septic shock in rats. 2017 Apr 1
28 28578430 Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord. 2017 Jun 2 2
29 26541177 Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. 2016 Mar 15 1
30 26986474 Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells. 2016 2
31 27158912 Myrtenal alleviates hyperglycaemia, hyperlipidaemia and improves pancreatic insulin level in STZ-induced diabetic rats. 2016 Nov 1
32 27225895 Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes. 2016 Aug 1
33 27684825 Atorvastatin inhibits insulin synthesis by inhibiting the Ras/Raf/ERK/CREB pathway in INS-1 cells. 2016 Sep 1
34 25701719 Physiological feedback regulation of cholesterol biosynthesis: Role of translational control of hepatic HMG-CoA reductase and possible involvement of oxylanosterols. 2015 May 2
35 26007644 Coenzyme Q10 remarkably improves the bio-energetic function of rat liver mitochondria treated with statins. 2015 Sep 5 1
36 26375281 Co-Administration of Cholesterol-Lowering Probiotics and Anthraquinone from Cassia obtusifolia L. Ameliorate Non-Alcoholic Fatty Liver. 2015 1
37 26442440 High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis. 2015 Oct 7 2
38 24505463 The regulation of alfalfa saponin extract on key genes involved in hepatic cholesterol metabolism in hyperlipidemic rats. 2014 1
39 25542004 A snapshot of the hepatic transcriptome: ad libitum alcohol intake suppresses expression of cholesterol synthesis genes in alcohol-preferring (P) rats. 2014 2
40 23147682 Dietary β-carotene regulates interleukin-1β-induced expression of apolipoprotein E in astrocytes isolated from stroke-prone spontaneously hypertensive rats. 2013 Jan 1
41 22274883 3-hydroxy 3-methylglutaryl coenzyme A reductase inhibition impairs muscle regeneration. 2012 Jun 1
42 22591135 Regulation of cholesterol biosynthetic pathway in different regions of the rat central nervous system. 2012 Sep 1
43 22613972 Hypothyroidism modifies lipid composition of polymorphonuclear leukocytes. 2012 1
44 23558989 Effects of simvastatin on bleomycin-induced pulmonary fibrosis in female rats. 2012 1
45 21178122 Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia. 2011 Mar 2
46 21414721 Statins alleviate experimental nerve injury-induced neuropathic pain. 2011 May 1
47 21906051 Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol-induced seizures. 2011 Nov 1
48 22082490 Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro. 2011 Nov 14 1
49 19895880 Hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A reductase regulation in aged female rats. 2010 Feb 2
50 19931295 Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. 2010 Feb 15 1