tanespimycin

N-methylpurine DNA glycosylase ; Homo sapiens







131 Article(s)
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1 34069389 17-AAG-Induced Activation of the Autophagic Pathway in Leishmania Is Associated with Parasite Death. 2021 May 19 1
2 32527461 Enzymatic biosynthesis and biological evaluation of novel 17-AAG glucoside as potential anti-cancer agents. 2020 Aug 1 1
3 32585150 Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake. 2020 Nov 3
4 30982499 Nonsteroidal Anti-inflammatory Drugs Sensitize CD44-Overexpressing Cancer Cells to Hsp90 Inhibitor Through Autophagy Activation. 2019 Jul 12 1
5 29297949 Effect of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on Akt protein expression is more effective in head and neck cancer cell lineages that retain PTEN protein expression. 2018 Mar 1
6 29317342 Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model. 2018 Apr 1
7 29676157 A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production. 2018 May 15 1
8 29800308 Heat shock protein 90α couples with the MAPK-signaling pathway to determine meiotic maturation of porcine oocytes. 2018 Jul 28 1
9 29953987 17-(Allylamino)-17-Demethoxygeldanamycin Enhances Etoposide-Induced Cytotoxicity via the Downregulation of Xeroderma Pigmentosum Complementation Group C Expression in Human Lung Squamous Cell Carcinoma Cells. 2018 1
10 30378153 17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death. 2018 Oct 30 1
11 28239659 Hsp90 regulation of fibroblast activation in pulmonary fibrosis. 2017 Feb 23 1
12 28336809 Lectin, Galactoside-Binding Soluble 3 Binding Protein Promotes 17-N-Allylamino-17-demethoxygeldanamycin Resistance through PI3K/Akt Pathway in Lung Cancer Cell Line. 2017 Jul 1
13 28789442 Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells. 2017 Aug 1
14 27075590 HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells. 2016 Jun 1
15 27279418 Effects of 17-AAG on the cell cycle and apoptosis of H446 cells and the associated mechanisms. 2016 Aug 1
16 27894402 HSP90 inhibitor enhances anti-proliferative and apoptotic effects of celecoxib on HT-29 colorectal cancer cells via increasing BAX/BCL-2 ratio. 2016 Oct 31 1
17 24277352 Up-regulation of Gadd45α after exposure to metal nanoparticles: the role of hypoxia inducible factor 1α. 2015 Apr 1
18 24623685 DNA aneuploidy-specific therapy for head and neck squamous cell carcinoma. 2015 Jun 1
19 26268232 [Effects of 17-AAG on the proliferation and apoptosis of human lung cancer A549 and H446 cells]. 2015 Apr 1
20 26313837 Heat Shock Protein 90 Inhibitor Decreases Collagen Synthesis of Keloid Fibroblasts and Attenuates the Extracellular Matrix on the Keloid Spheroid Model. 2015 Sep 1
21 26501082 Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. 2015 1
22 24166505 HSP-90 inhibitor ganetespib is synergistic with doxorubicin in small cell lung cancer. 2014 Oct 2 1
23 24303801 Novel mechanism of attenuation of LPS-induced NF-κB activation by the heat shock protein 90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin, in human lung microvascular endothelial cells. 2014 May 1
24 24317439 The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway. 2014 Feb 2
25 24718854 Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer. 2014 Jun 1
26 24798692 Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells. 2014 May 15 1
27 24879994 SNX-25a, a novel Hsp90 inhibitor, inhibited human cancer growth more potently than 17-AAG. 2014 Jul 18 1
28 24886060 Use of NQO1 status as a selective biomarker for oesophageal squamous cell carcinomas with greater sensitivity to 17-AAG. 2014 May 15 1
29 25227799 Comparison of inhibitory effects of 17-AAG nanoparticles and free 17-AAG on HSP90 gene expression in breast cancer. 2014 1
30 22955701 The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells. 2013 Nov 1
31 23229511 Aryl hydrocarbon receptor is a target of 17-Allylamino-17-demethoxygeldanamycin and enhances its anticancer activity in lung adenocarcinoma cells. 2013 Mar 1
32 23564374 Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors. 2013 May 1
33 23629654 Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation. 2013 Jun 14 2
34 23886587 The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition. 2013 Nov 2
35 24012704 Formulation and in vitro evaluation of 17-allyamino-17-demethoxygeldanamycin (17-AAG) loaded polymeric mixed micelles for glioblastoma multiforme. 2013 Dec 1 1
36 24185264 Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. 2013 Nov 1
37 20683637 A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma. 2012 Feb 1
38 21830942 Cooperative enhancement of radiosensitivity after combined treatment of 17-(allylamino)-17-demethoxygeldanamycin and celecoxib in human lung and colon cancer cell lines. 2012 Jan 1
39 22099584 Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG. 2012 Jul 1
40 22377218 Folate receptor targeted 17-allylamino-17-demethoxygeldanamycin (17-AAG) loaded polymeric nanoparticles for breast cancer. 2012 Jun 1 2
41 22566604 Inhibition of the mTORC2 and chaperone pathways to treat leukemia. 2012 Jun 21 1
42 22621282 Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy. 2012 May 23 1
43 22687408 The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells. 2012 1
44 22711259 17-allylamino-17-(demethoxy)geldanamycin (17-AAG) is a potent and effective inhibitor of human cytomegalovirus replication in primary fibroblast cells. 2012 Oct 2
45 23650580 The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes. 2012 1
46 20816782 17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy. 2011 Jan 1
47 21517103 Nano self-assembly of recombinant human gelatin conjugated with α-tocopheryl succinate for Hsp90 inhibitor, 17-AAG, delivery. 2011 May 24 1
48 21542685 Synergistic administration of photothermal therapy and chemotherapy to cancer cells using polypeptide-based degradable plasmonic matrices. 2011 Apr 1
49 21558407 HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. 2011 Aug 1 2
50 21820041 Multi-drug delivery to tumor cells via micellar nanocarriers. 2011 Oct 31 1