Proline

Cbl proto-oncogene ; Homo sapiens







32 Article(s)
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1 33512474 CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1. 2021 Apr 22 2
2 33627783 E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis. 2021 Mar 2
3 31123462 C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6. 2019 1
4 22310290 CBL enhances breast tumor formation by inhibiting tumor suppressive activity of TGF-β signaling. 2012 Dec 13 1
5 22315494 CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2. 2012 Aug 2
6 21830225 SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. 2011 Oct 1
7 19268472 Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications. 2009 Apr 17 1
8 18680311 Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. 2008 Aug 26 1
9 17237826 c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl. 2007 Jun 14 1
10 16407834 Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix. 2006 May 18 1
11 16906159 Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. 2006 Sep 1
12 17094785 Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl. 2006 Dec 7
13 15872089 Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. 2005 Jul 2
14 16228008 Cbl promotes clustering of endocytic adaptor proteins. 2005 Nov 1
15 12618476 CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities. 2003 Mar 1
16 12839496 Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation. 2003 Aug 2
17 12874286 Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. 2003 Oct 10 2
18 12941616 A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes. 2003 Sep 10 1
19 11964172 Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement. 2002 May 1 1
20 11067845 The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. 2001 Feb 16 1
21 11494134 Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor. 2001 Jul 5 2
22 9890943 Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120(Cbl). 1999 Jan 22 2
23 10022120 Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. 1999 Feb 4 2
24 10521482 Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor. 1999 Oct 22 2
25 9712732 Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl. 1998 Aug 19 1
26 9797470 c-Cbl: a regulator of T cell receptor-mediated signalling. 1998 Oct 1
27 9121472 Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. 1997 Apr 1
28 9259313 Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase. 1997 Aug 2
29 9622055 The Cbl family of signal transduction molecules. 1997 1
30 7592693 Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor. 1995 Oct 27 2
31 7791764 Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells. 1995 Jul 1
32 1565471 A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein. 1992 Apr 1