Leucovorin

dihydrofolate reductase ; Homo sapiens







8 Article(s)
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Title
Pub. Year
#Total Relationships
1 21310277 Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. 2011 Feb 11 1
2 19666584 Pivotal role of dihydrofolate reductase knockdown in the anticancer activity of 2-hydroxyoleic acid. 2009 Aug 18 1
3 16712799 Leucovorin-induced resistance against FDH growth suppressor effects occurs through DHFR up-regulation. 2006 Jul 14 1
4 12467717 Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies. 2003 Jan 2 2
5 10499129 Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry. 1998 Apr 1
6 7562910 Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. 1995 Sep 15 1
7 2260989 Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells. 1990 Dec 15 4
8 2448654 Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. 1987 5