piritrexim

dihydrofolate reductase ; Homo sapiens







11 Article(s)
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PMID
Title
Pub. Year
#Total Relationships
1 21206056 Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives. 2011 Jan 2
2 17346178 Dihydrofolate reductase as a target for chemotherapy in parasites. 2007 2
3 12110313 QSAR studies on biological activity of piritrexim analogues against pc DHFR. 2002 Sep 5
4 11996001 Computer modeling studies of the structural role of NADPH binding to active site mutants of human dihydrofolate reductase in complex with piritrexim. 2001 3
5 10683342 Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. 2000 Mar 1 1
6 7799402 2,4-Diamino-5-chloroquinazoline analogues of trimetrexate and piritrexim: synthesis and antifolate activity. 1994 Dec 23 2
7 8431372 Oral piritrexim, an effective treatment for metastatic urothelial cancer. 1993 Feb 3
8 2967669 Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate. 1988 Apr 2
9 3323908 Initial clinical studies of piritrexim. 1987 4
10 3431588 Preclinical biochemical pharmacology and toxicology of piritrexim, a lipophilic inhibitor of dihydrofolate reductase. 1987 1
11 7155133 Metabolic inhibition by a new antifolate, 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methyl-pyrido[2,3-d]pyrimidine (BW3O1U), an effective inhibitor of human lymphoid and dihydrofolate reductase-overproducing mouse cell lines. 1982 Nov 1