Tyrosine

neurotrophic receptor tyrosine kinase 1 ; Homo sapiens







81 Article(s)
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1 31870220 Molecular dynamics simulation and free energy calculation studies of the binding mechanism of allosteric inhibitors with TrkA kinase. 2021 Jan 2
2 32044823 NTRK-rearranged Cervical Sarcoma: Expanding the Clinicopathologic Spectrum. 2021 Jan 2
3 31760089 Molecular insight on the altered membrane trafficking of TrkA kinase dead mutants. 2020 Feb 1
4 31761448 Evidence of NTRK1 Fusion as Resistance Mechanism to EGFR TKI in EGFR+ NSCLC: Results From a Large-Scale Survey of NTRK1 Fusions in Chinese Patients With Lung Cancer. 2020 May 1
5 31971278 NTRK fusion cervical sarcoma: a report of three cases, emphasising morphological and immunohistochemical distinction from other uterine sarcomas, including adenosarcoma. 2020 Jul 1
6 32024191 hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay. 2020 Feb 1 1
7 32050835 Myxoid Spindle Cell Sarcoma With LMNA-NTRK Fusion: Expanding the Morphologic Spectrum of NTRK-Rearranged Tumors. 2020 Aug 1
8 33239753 Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling. 2020 Nov 25 3
9 31681584 Two Receptors, Two Isoforms, Two Cancers: Comprehensive Analysis of KIT and TrkA Expression in Neuroblastoma and Acute Myeloid Leukemia. 2019 1
10 31928627 Trk receptor tyrosine kinases in metastasis and cancer therapy. 2019 Oct 1
11 29360440 A novel in-cell ELISA method for screening of compounds inhibiting TRKA phosphorylation, using KM12 cell line harboring TRKA rearrangement. 2018 Mar 15 1
12 29715200 TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. 2018 Jul 2 1
13 28315978 The hallucinogen 2,5-dimethoxy-4-iodoamphetamine hydrochloride activates neurotrophin receptors in a neuronal cell line and promotes neurites extension. 2017 Jun 1
14 25330101 Dehydroepiandrosterone: an ancestral ligand of neurotrophin receptors. 2015 Jan 1
15 25708205 Amyloid β-abrogated TrkA ubiquitination in PC12 cells analogous to Alzheimer's disease. 2015 Jun 1
16 24239780 Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells. 2014 Jan 30 2
17 24375967 Proteomic analysis of SP600125-controlled TrkA-dependent targets in SK-N-MC neuroblastoma cells: inhibition of TrkA activity by SP600125. 2014 Feb 1
18 24470253 Structural insights into FRS2α PTB domain recognition by neurotrophin receptor TrkB. 2014 Jul 1
19 23266087 Receptor tyrosine kinase signaling mechanisms: Devolving TrkA responses with phosphoproteomics. 2013 Jan 1
20 23319303 Proteomic analysis of novel targets associated with TrkA-mediated tyrosine phosphorylation signaling pathways in SK-N-MC neuroblastoma cells. 2013 Jan 5
21 23589303 Dissecting the roles of tyrosines 490 and 785 of TrkA protein in the induction of downstream protein phosphorylation using chimeric receptors. 2013 Jun 7 5
22 23674677 Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs. 2013 May 28 2
23 22496904 NGF causes TrkA to specifically attract microtubules to lipid rafts. 2012 2
24 22992069 Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family. 2012 Dec 1 1
25 23035300 Brain-Derived Neurotrophic Factor in Suicide Pathophysiology 2012 2
26 21184737 Ectopic expression of H2AX protein promotes TrkA-induced cell death via modulation of TrkA tyrosine-490 phosphorylation and JNK activity upon DNA damage. 2011 Jan 21 6
27 21279681 Generation of TrkA/TrkB chimeric receptor constructs reveals molecular mechanisms underlying BDNF-induced dendritic outgrowth in hippocampal neurons. 2011 May 1
28 20219970 Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation. 2010 May 1 2
29 20977883 Caveolin-1 inhibits TrkA-induced cell death by influencing on TrkA modification associated with tyrosine-490 phosphorylation. 2010 Nov 26 4
30 19749791 Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation. 2009 Oct 29 3
31 18173729 Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function. 2008 Jan 4
32 18285558 Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes. 2008 Apr 2
33 18477627 Protein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cells. 2008 Aug 3
34 16914291 The neuropeptide pituitary adenylate cyclase activating protein stimulates human monocytes by transactivation of the Trk/NGF pathway. 2007 Jan 1
35 17409494 A novel cyclophane compound, CPPy, facilitates NGF-induced TrkA signal transduction and induces cell differentiation in neuroblastoma. 2007 Apr 1
36 17520746 Copper activates TrkB in cortical neurons in a metalloproteinase-dependent manner. 2007 Aug 1 1
37 15601748 Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA. 2005 Feb 1
38 15825190 Early apoptotic and late necrotic components associated with altered Ca2+ homeostasis in a peptide-delivery model of polyglutamine-induced neuronal death. 2005 May 15 1
39 15153516 C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1. 2004 Jun 1 2
40 15167895 A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein. 2004 Jun 16 1
41 14647472 Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-dependent, but not nerve growth factor-independent, differentiation and cell cycle arrest in the human neuroblastoma cell line, SY5Y. 2003 Nov 27 1
42 11866461 Constitutive TrkA activity in receptor-overexpressing PC12 clones. 2002 Mar 8 1
43 11901208 p75-nerve growth factor as an antiapoptotic complex: independence versus cooperativity in protection from enediyne chemotherapeutic agents. 2002 Apr 2
44 12150951 Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP. 2002 Jul 12 2
45 12419535 Distinct usages of phospholipase C gamma and Shc in intracellular signaling stimulated by neurotrophins. 2002 Nov 15 1
46 12829403 Gangliosides prevent excitotoxicity through activation of TrkB receptor. 2002 May 1
47 11285228 Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways. 2001 Apr 2 1
48 10617652 A novel apoptotic pathway induced by nerve growth factor-mediated TrkA activation in medulloblastoma. 2000 Jan 7 1
49 10656690 Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation. 2000 Jan 20 4
50 10841774 Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1). 2000 Jun 13 1