| 1 |
30902024 | Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine. | 2020 Feb |
2 |
| 2 |
32817462 | Tyrosine Nitration Contributes to Nitric Oxide-Stimulated Degradation of CYP2B6. | 2020 Sep |
2 |
| 3 |
30589555 | Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches. | 2019 Feb 4 |
1 |
| 4 |
31375472 | Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes). | 2019 Oct |
1 |
| 5 |
30205091 | Methadone Metabolism and Drug-Drug Interactions: In Vitro and In Vivo Literature Review. | 2018 Dec |
1 |
| 6 |
27185541 | Identification of in vitro and in vivo human metabolites of the new psychoactive substance nitracaine by liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. | 2016 Jul |
1 |
| 7 |
26276083 | Toxicokinetics of lefetamine and derived diphenylethylamine designer drugs-Contribution of human cytochrome P450 isozymes to their main phase I metabolic steps. | 2015 Nov 4 |
1 |
| 8 |
24477223 | Pharmacogenetics and clinical biomarkers for subtherapeutic plasma efavirenz concentration in HIV-1 infected Thai adults. | 2014 |
1 |
| 9 |
23298862 | Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6. | 2013 Apr |
4 |
| 10 |
23361846 | Role of cytochrome P4502B6 in methadone metabolism and clearance. | 2013 Mar |
1 |
| 11 |
23550066 | The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro. | 2013 Jun |
1 |
| 12 |
23592585 | How is a metabolic intermediate formed in the mechanism-based inactivation of cytochrome P450 by using 1,1-dimethylhydrazine: hydrogen abstraction or nitrogen oxidation? | 2013 Jun 3 |
1 |
| 13 |
23774830 | Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn. | 2013 Jul |
1 |
| 14 |
22349139 | In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opioid metabolite nortilidine to bisnortilidine. | 2012 Jun |
1 |
| 15 |
22511698 | Evaluating the relationship of methadone concentrations and EDDP formation in chronic pain patients. | 2012 May |
1 |
| 16 |
22023129 | Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans. | 2011 Nov |
1 |
| 17 |
19089010 | Theoretical study of N-dealkylation of N-cyclopropyl-N-methylaniline catalyzed by cytochrome P450: insight into the origin of the regioselectivity. | 2009 Jan 14 |
1 |
| 18 |
18292673 | Role of CYP2B6 in stereoselective human methadone metabolism. | 2008 Mar |
2 |
| 19 |
18563875 | How do azoles inhibit cytochrome P450 enzymes? A density functional study. | 2008 Dec 18 |
1 |
| 20 |
18725511 | The role of human hepatic cytochrome P450 isozymes in the metabolism of racemic 3,4-methylenedioxy-methamphetamine and its enantiomers. | 2008 Nov |
2 |
| 21 |
17259447 | Enantiomeric metabolic interactions and stereoselective human methadone metabolism. | 2007 Apr |
2 |
| 22 |
16214851 | Role of human cyclooxygenase-2 in the bioactivation of dapsone and sulfamethoxazole. | 2006 Jan |
1 |
| 23 |
15686361 | P(450)/NADPH/O(2)- and P(450)/PhIO-catalyzed N-dealkylations are mechanistically distinct. | 2005 Feb 9 |
1 |
| 24 |
15821045 | Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. | 2005 Jul |
1 |
| 25 |
15078194 | The role of genetic polymorphisms in metabolism of carcinogenic heterocyclic aromatic amines. | 2004 Apr |
1 |
| 26 |
15319333 | CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. | 2004 Sep |
1 |
| 27 |
15365656 | Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. | 2004 Oct |
1 |
| 28 |
12519691 | Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine. | 2003 Jan |
1 |
| 29 |
12527701 | Comparison of the formation of N-alkylprotoporphyrin IX after interaction of porphyrinogenic xenobiotics with single cDNA-expressed human P450 enzymes in microsomes prepared from baculovirus-infected insect cells and human lymphoblastoid cell lines. | 2003 Feb |
1 |
| 30 |
12721102 | Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. | 2003 Apr |
1 |
| 31 |
12844133 | Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9. | 2003 Jul |
1 |
| 32 |
12975333 | In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes. | 2003 Oct |
1 |
| 33 |
12351147 | Metabolic oxidation of carcinogenic arylamines by p450 monooxygenases: theoretical support for the one-electron transfer mechanism. | 2002 Sep 30 |
1 |
| 34 |
12433806 | Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes. | 2002 Dec |
2 |
| 35 |
15618670 | Metabolism of selegiline hydrochloride, a selective monoamine b-type inhibitor, in human liver microsomes. | 2002 |
1 |
| 36 |
11259560 | Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. | 2001 Apr |
1 |
| 37 |
11353758 | Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes. | 2001 Jun |
5 |
| 38 |
11396966 | Differential N-demethylation of l-alpha-acetylmethadol (LAAM) and norLAAM by cytochrome P450s 2B6, 2C18, and 3A4. | 2001 Jun 15 |
1 |
| 39 |
10692561 | Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. | 2000 Apr 15 |
2 |
| 40 |
10799653 | Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs. | 2000 Jun 15 |
1 |
| 41 |
10101147 | Monospecific antipeptide antibody to cytochrome P-450 2B6. | 1999 Apr |
1 |
| 42 |
10101149 | Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes. | 1999 Apr |
1 |
| 43 |
10534317 | Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer. | 1999 Nov |
1 |
| 44 |
10570024 | Role of human CYP2B6 in S-mephobarbital N-demethylation. | 1999 Dec |
2 |
| 45 |
9698292 | Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6. | 1998 Aug |
1 |
| 46 |
8764331 | Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers. | 1996 Jul |
1 |
| 47 |
8886603 | Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin. | 1996 Sep |
1 |
| 48 |
8902262 | A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108. | 1996 Oct-Nov |
2 |
| 49 |
8274159 | Cytochrome P450 dependent N-hydroxylation of a guanidine (debrisoquine), microsomal catalysed reduction and further oxidation of the N-hydroxy-guanidine metabolite to the urea derivative. Similarity with the oxidation of arginine to citrulline and nitric oxide. | 1993 Dec 14 |
3 |
| 50 |
8330339 | Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes. | 1993 Jul |
1 |