| 1 |
34648192 | Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4-methylaminoantipyrine. | 2022 Feb |
1 |
| 2 |
35179893 | Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles. | 2022 Mar 10 |
1 |
| 3 |
33479614 | Conversion of amino acids to aryl/heteroaryl ethanol metabolites using human CYP2D6-expressing live baker's yeast. | 2020 Jan 1 |
1 |
| 4 |
30312494 | Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients. | 2019 Jan |
7 |
| 5 |
29881433 | Gender Dependency in Streoselective Pharmacokinetics of Tramadol and Its Phase I Metabolites in Relation to CYP2D6 Phenotype in Iranian Population. | 2018 Spring |
1 |
| 6 |
30205091 | Methadone Metabolism and Drug-Drug Interactions: In Vitro and In Vivo Literature Review. | 2018 Dec |
1 |
| 7 |
26856397 | Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3. | 2016 Mar |
2 |
| 8 |
25475885 | Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients. | 2015 Jan 1 |
1 |
| 9 |
26456786 | Low resolution and high resolution MS for studies on the metabolism and toxicological detection of the new psychoactive substance methoxypiperamide (MeOP). | 2015 Oct |
1 |
| 10 |
24010633 | Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6. | 2014 Apr |
2 |
| 11 |
23361230 | 2-methiopropamine, a thiophene analogue of methamphetamine: studies on its metabolism and detectability in the rat and human using GC-MS and LC-(HR)-MS techniques. | 2013 Apr |
1 |
| 12 |
23552177 | Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation. | 2013 Jul |
2 |
| 13 |
23640382 | Stereoselectivity in the cytochrome P450-dependent N-demethylation and flavin monooxygenase-dependent N-oxidation of N,N-dimethylamphetamine. | 2013 Nov |
1 |
| 14 |
22372551 | Molecular analysis and modeling of inactivation of human CYP2D6 by four mechanism based inactivators. | 2012 Mar |
1 |
| 15 |
22459173 | Binding of quinidine radically increases the stability and decreases the flexibility of the cytochrome P450 2D6 active site. | 2012 May |
2 |
| 16 |
19601803 | Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development. | 2009 |
2 |
| 17 |
19645588 | New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. | 2009 |
1 |
| 18 |
17764997 | Analysis of CYP2D6 substrate interactions by computational methods. | 2008 Feb |
1 |
| 19 |
18524873 | Novel binding mode of the acidic CYP2D6 substrates pactimibe and its metabolite R-125528. | 2008 Sep |
2 |
| 20 |
18725510 | The molecular basis of CYP2D6-mediated N-dealkylation: balance between metabolic clearance routes and enzyme inhibition. | 2008 Nov |
3 |
| 21 |
17020955 | Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. | 2007 Jan |
1 |
| 22 |
16272405 | Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine. | 2006 Mar |
1 |
| 23 |
16432914 | Roles of phenylalanine at position 120 and glutamic acid at position 222 in the oxidation of chiral substrates by cytochrome P450 2D6. | 2006 Feb |
1 |
| 24 |
16510126 | Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes. | 2006 Apr 28 |
1 |
| 25 |
15585365 | Characterization of human liver cytochrome P450 enzymes involved in the metabolism of a new H+/K+-ATPase inhibitor KR-60436. | 2005 Jan 15 |
1 |
| 26 |
16135359 | The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent. | 2005 Oct 15 |
1 |
| 27 |
16269134 | Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6. | 2005 Dec 16 |
1 |
| 28 |
14992686 | Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite. | 2004 Jun 1 |
2 |
| 29 |
15365656 | Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. | 2004 Oct |
1 |
| 30 |
12446689 | Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. | 2003 Feb 7 |
2 |
| 31 |
12433806 | Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes. | 2002 Dec |
1 |
| 32 |
11504269 | Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations. | 2001 Aug |
2 |
| 33 |
11519155 | [Pharmacokinetics and drug interactions of antidepressive agents]. | 2001 Aug |
1 |
| 34 |
11602510 | Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6. | 2001 Nov |
1 |
| 35 |
10752644 | Metabolism of N,N-dialkylated amphetamines, including deprenyl, by CYP2D6 expressed in a human cell line. | 2000 Mar |
1 |
| 36 |
11095593 | Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity. | 2000 Dec |
1 |
| 37 |
11102743 | Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin. | 2000 Dec |
1 |
| 38 |
10359460 | Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine. | 1999 Apr 1 |
1 |
| 39 |
10421623 | In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine. | 1999 Aug |
1 |
| 40 |
10493260 | Cytochrome P450 CYP2D6. | 1999 |
2 |
| 41 |
9560305 | Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity. | 1998 May 1 |
1 |
| 42 |
9733666 | Interaction of terfenadine and its primary metabolites with cytochrome P450 2D6. | 1998 Sep |
1 |
| 43 |
9110356 | Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes. | 1997 Feb |
1 |
| 44 |
9143866 | Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. | 1997 |
2 |
| 45 |
9311621 | Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6. | 1997 Sep |
1 |
| 46 |
8627546 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease. | 1996 May |
2 |
| 47 |
8660692 | Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants. | 1996 Jul 1 |
2 |
| 48 |
8712396 | Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. | 1996 Jan |
1 |
| 49 |
8764331 | Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers. | 1996 Jul |
1 |
| 50 |
8877032 | Variable contribution of CYP2D6 to the N-dealkylation of S-(-)-propranolol by human liver microsomes. | 1996 Sep |
3 |