2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

C-X-C motif chemokine ligand 8 ; Homo sapiens







43 Article(s)
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1 33505496 Effect and Molecular Mechanisms of Jiedu Recipe on Hypoxia-Induced Angiogenesis after Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma. 2021 3
2 34227646 Resveratrol prevents inflammation and oxidative stress response in LPS-induced human gingival fibroblasts by targeting the PI3K/AKT and Wnt/β-catenin signaling pathways. 2021 1
3 32112175 PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma. 2020 Feb 28 1
4 31636329 Mitochondrial dysfunction increases pro-inflammatory cytokine production and impairs repair and corticosteroid responsiveness in lung epithelium. 2019 Oct 21 1
5 31684995 Interleukin-8 promotes integrin β3 upregulation and cell invasion through PI3K/Akt pathway in hepatocellular carcinoma. 2019 Nov 4 1
6 29175450 Crosstalk between mAChRM3 and β2AR, via acetylcholine PI3/PKC/PBEP1/Raf-1 MEK1/2/ERK1/2 pathway activation, in human bronchial epithelial cells after long-term cigarette smoke exposure. 2018 Jan 1 1
7 29402343 MicroRNA-204 Inhibits the Growth and Motility of Colorectal Cancer Cells by Downregulation of CXCL8. 2018 Sep 14 1
8 29908644 Cadmium induces inflammatory cytokines through activating Akt signaling in mouse placenta and human trophoblast cells. 2018 May 1
9 28371277 Overexpression of microRNA-138 alleviates human coronary artery endothelial cell injury and inflammatory response by inhibiting the PI3K/Akt/eNOS pathway. 2017 Aug 1
10 29290940 Lysophosphatidylcholine induces cytotoxicity/apoptosis and IL-8 production of human endothelial cells: Related mechanisms. 2017 Dec 5 1
11 27588140 IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling. 2016 Sep 1
12 27740938 7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells. 2016 Nov 15 1
13 25748730 Paeoniflorin diminishes ConA-induced IL-8 production in primary human hepatic sinusoidal endothelial cells in the involvement of ERK1/2 and Akt phosphorylation. 2015 May 2
14 26121010 Activation of IL-8 via PI3K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells. 2015 1
15 24669186 Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells. 2014 2
16 25058399 Roles of PI3K/Akt and c-Jun signaling pathways in human papillomavirus type 16 oncoprotein-induced HIF-1α, VEGF, and IL-8 expression and in vitro angiogenesis in non-small cell lung cancer cells. 2014 1
17 23403077 Role of MIF/CXCL8/CXCR2 signaling in the growth of nasopharyngeal carcinoma tumor spheres. 2013 Jul 10 1
18 21545687 Regulatory mechanisms of interleukin-8 production induced by tumour necrosis factor-α in human hepatocellular carcinoma cells. 2012 Mar 1
19 22420994 Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes. 2012 Mar 15 1
20 22610073 As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling. 2012 Jul 1
21 21215400 Involvement of cholesterol-enriched microdomains in class A scavenger receptor-mediated responses in human macrophages. 2011 Mar 1
22 21266580 Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway. 2011 Mar 25 4
23 21468084 Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases. 2011 Apr 1
24 20451499 Thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell. 2010 Jun 4 1
25 19103208 HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling. 2009 Mar 1
26 20050188 Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts. 2009 Dec 1
27 17786963 Differential signaling mechanisms of HNP-induced IL-8 production in human lung epithelial cells and monocytes. 2008 Mar 1
28 18854173 PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells. 2008 Dec 12 1
29 17130184 Cofilin plays a critical role in IL-8-dependent chemotaxis of neutrophilic HL-60 cells through changes in phosphorylation. 2007 Mar 1
30 17314215 Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. 2007 Jun 2
31 17606477 Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. 2007 Jul 1
32 16253565 Double-stranded RNA induces production of RANTES and IL-8 by human nasal fibroblasts. 2006 Jan 1
33 16761312 Signaling events involved in cytokine and chemokine production induced by secretory phospholipase A2 in human lung macrophages. 2006 Jul 1
34 16794257 Quercetin blocks airway epithelial cell chemokine expression. 2006 Nov 1
35 16798838 Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis. 2006 Aug 2
36 16269654 Adiponectin inhibits endothelial synthesis of interleukin-8. 2005 Dec 9 2
37 12588890 Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. 2003 Feb 1
38 11971003 Signaling pathways involved in IL-8-dependent activation of adhesion through Mac-1. 2002 May 1 2
39 12379708 Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. 2002 Nov 1
40 11479233 Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. 2001 Aug 1 2
41 10754327 Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways. 2000 Apr 15 2
42 11028544 TNFalpha-induced suppression of PMN apoptosis is mediated through interleukin-8 production. 2000 Sep 1
43 9096344 Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases. 1997 Apr 1 1