Cholesterol

sterol O-acyltransferase 1 ; Homo sapiens







147 Article(s)
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1 34670102 SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation. 2022 Feb 5
2 34914638 Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in mice. 2022 Feb 8 1
3 35359411 Transcriptomics Reveals the Mevalonate and Cholesterol Pathways Blocking as Part of the Bacterial Cyclodipeptides Cytotoxic Effects in HeLa Cells of Human Cervix Adenocarcinoma. 2022 1
4 35398929 P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis. 2022 Apr 10 2
5 35409086 SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma? 2022 Mar 28 2
6 35598637 Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans. 2022 May 19 3
7 33454379 Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer. 2021 Apr 2
8 33637695 Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer. 2021 Feb 26 4
9 34207810 TNFα-Induced LDL Cholesterol Accumulation Involve Elevated LDLR Cell Surface Levels and SR-B1 Downregulation in Human Arterial Endothelial Cells. 2021 Jun 9 1
10 34326474 High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer. 2021 Jul 29 3
11 34436484 Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era. 2021 Aug 14 2
12 34460058 SOAT1 is a new prognostic factor of colorectal cancer. 2021 Aug 30 2
13 34790132 SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis. 2021 1
14 31963898 Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma. 2020 Jan 19 2
15 32433613 Structure of nevanimibe-bound tetrameric human ACAT1. 2020 May 1
16 32646751 Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterol crystal formation in Endothelial cells partly through modulation of Lysosomal pH and Cholesterol homeostasis. 2020 Sep 1
17 32698040 Cholesterol metabolism: New functions and therapeutic approaches in cancer. 2020 Aug 1
18 32735863 Nanodisc scaffold peptide (NSPr) replaces detergent by reconstituting acyl-CoA:cholesterol acyltransferase 1 into peptidiscs. 2020 Sep 30 2
19 32739420 Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome. 2020 Nov 4
20 30578317 The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. 2019 Jan 16 2
21 30814741 Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. 2019 Mar 2
22 31681760 Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis. 2019 1
23 31766415 Anti-ApoA-1 IgGs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation. 2019 Nov 21 1
24 29282984 Cholesterol Oxidase/Triton X-100 Parked Microelectrodes for the Detection of Cholesterol in Plasma Membrane at Single Cells. 2018 Jan 16 1
25 29753268 Bio-activity of aminosulfonyl ureas in the light of nucleic acid bases and DNA base pair interaction. 2018 Aug 1
26 28192948 C3N4 Nanosheet Modified Microwell Array with Enhanced Electrochemiluminescence for Total Analysis of Cholesterol at Single Cells. 2017 Feb 21 3
27 28242547 Vicinal diaryl azole-based urea derivatives as potential cholesterol lowering agents acting through inhibition of SOAT enzymes. 2017 Apr 21 1
28 26497474 ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis. 2016 Jan 1
29 27281560 Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis. 2016 Nov 1 4
30 27570155 Quantitative Metabolomic Profiling of Plasma, Urine, and Liver Extracts by 1H NMR Spectroscopy Characterizes Different Stages of Atherosclerosis in Hamsters. 2016 Oct 7 1
31 24328095 Fast serial analysis of active cholesterol at the plasma membrane in single cells. 2014 Jan 7 1
32 23169578 The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes. 2013 Feb 1
33 23198718 ACAT inhibitors: the search for novel cholesterol lowering agents. 2013 Jun 1 4
34 23305686 Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells. 2013 Mar 2
35 23527944 Luminol electrochemiluminescence for the analysis of active cholesterol at the plasma membrane in single mammalian cells. 2013 Apr 16 2
36 19228775 Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters. 2011 2
37 21239516 Sterol O-acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal. 2011 Apr 5
38 20403694 First identification of xanthone sulfonamides as potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors. 2010 May 15 1
39 20546600 Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study. 2010 Jun 14 2
40 19502590 Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion. 2009 Nov 3
41 19515767 Role of cholesterol pathways in norovirus replication. 2009 Sep 2
42 19746448 Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments. 2009 Dec 1 2
43 19884502 Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. 2009 Nov 17 2
44 18212280 Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis. 2008 Feb 5 1
45 18322393 ACAT as a drug target for Alzheimer's disease. 2008 2
46 16973241 Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis. 2007 Jan 1
47 17576822 Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells. 2007 Nov 2
48 18281742 Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet. 2007 Dec 1
49 16157345 Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. 2006 Jun 1
50 16466701 Hexadecylphosphocholine disrupts cholesterol homeostasis and induces the accumulation of free cholesterol in HepG2 tumour cells. 2006 Apr 14 2