shikonin

pyruvate kinase M1/2 ; Homo sapiens







16 Article(s)
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1 35241524 PKM2 Is Overexpressed in Glioma Tissues, and Its Inhibition Highly Increases Late Apoptosis in U87MG Cells With Low-density Specificity. 2022 Mar-Apr 2
2 33220292 Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line. 2021 Jan 15 4
3 34234853 Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation. 2021 5
4 34348626 Rationalization of the activity Profile of Pyruvate Kinase Isozyme M2 (PKM2) Inhibitors using 3D QSAR. 2021 3
5 34354861 Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma. 2021 3
6 34752817 Shikonin alleviates choroidal neovascularization by inhibiting proangiogenic factor production from infiltrating macrophages. 2021 Dec 4
7 31819190 Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2). 2020 Jan 2
8 32487192 PKM2 inhibition may reverse therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma. 2020 Jun 3 1
9 32774157 TET2 suppresses nasopharyngeal carcinoma progression by inhibiting glycolysis metabolism. 2020 1
10 32878800 Antitumor Effect of Shikonin, a PKM2 Inhibitor, in Cholangiocarcinoma Cell Lines. 2020 Sep 2
11 30911326 Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation. 2019 3
12 31246990 Tumor M2-PK: A novel urine marker of bladder cancer. 2019 4
13 29185365 Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform. 2018 Dec 1
14 29608987 RIP1 and RIP3 contribute to shikonin-induced glycolysis suppression in glioma cells via increase of intracellular hydrogen peroxide. 2018 Jul 1 1
15 24710512 Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells. 2014 2
16 25587028 Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma. 2014 Dec 30 1