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33672922 | Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice. | 2021 Feb 14 |
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34019427 | Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry. | 2021 Jun 7 |
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34145064 | Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures. | 2021 Sep |
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| 4 |
32512884 | Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime. | 2020 Jun 4 |
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| 5 |
31207225 | Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects. | 2019 Aug 25 |
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25346249 | In vivo protection of diisopropylphosphorofluoridate (DFP) poisoning by three bis-quaternary 2 -(hydroxyimino) -N -(pyridin-3-yl) acetamide derivatives in Swiss mice. | 2014 Oct 25 |
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| 7 |
22343626 | Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. | 2012 Apr 6 |
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| 8 |
22385173 | An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning. | 2012 Mar |
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| 9 |
22731788 | First principles calculations of thermodynamics and kinetic parameters and molecular dynamics simulations of acetylcholinesterase reactivators: can mouse data provide new insights into humans? | 2012 |
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| 10 |
20140002 | Differential binding of bispyridinium oxime drugs with acetylcholinesterase. | 2010 Mar |
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20385200 | Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro. | 2010 Jun 4 |
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20406208 | In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase. | 2010 Sep |
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20408892 | Cholinergic stimulation of the immune system protects against lethal infection by Salmonella enterica serovar Typhimurium. | 2010 Jul |
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| 14 |
18950608 | Butane-2,3-dionethiosemicarbazone: an oxime with antioxidant properties. | 2009 Jan 27 |
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18035420 | Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex. | 2008 Jan |
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| 16 |
18504554 | Antioxidant properties of oxime 3-(phenylhydrazono) butan-2-one. | 2008 Oct |
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| 17 |
18523134 | Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase. | 2008 Sep |
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18975951 | Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation. | 2008 Nov 26 |
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| 19 |
17046138 | Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates. | 2007 Apr 20 |
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| 20 |
17402711 | Crystal structures of acetylcholinesterase in complex with organophosphorus compounds suggest that the acyl pocket modulates the aging reaction by precluding the formation of the trigonal bipyramidal transition state. | 2007 Apr 24 |
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| 21 |
16332406 | In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity. | 2006 Feb 15 |
4 |
| 22 |
16598855 | Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP. | 2006 Apr 14 |
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| 23 |
16782588 | The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure. | 2006 Jun |
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| 24 |
16876764 | Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates. | 2006 Aug 28 |
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| 25 |
17192653 | Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice. | 2006 |
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| 26 |
15679473 | Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. | 2005 Feb |
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| 27 |
16040183 | Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon. | 2005 Oct 30 |
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| 28 |
15023072 | Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates. | 2004 Mar 23 |
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15065394 | [Effect of acetylcholinesterase reactivator dosage on its effectiveness in the treatment of tabun poisoning in mice]. | 2004 Jan |
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10421446 | Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime. | 1999 May 14 |
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| 31 |
10421479 | Improvements in scavenger protection against organophosphorus agents by modification of cholinesterases. | 1999 May 14 |
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9271331 | Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning. | 1997 Jul 15 |
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8304979 | Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes. | 1994 Jan 20 |
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6710513 | Profenofos insecticide bioactivation in relation to antidote action and the stereospecificity of acetylcholinesterase inhibition, reactivation, and aging. | 1984 Mar 30 |
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