7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione

baculoviral IAP repeat containing 3 ; Homo sapiens







8 Article(s)
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1 34377229 Kras mutation subtypes distinctly affect colorectal cancer cell sensitivity to FL118, a novel inhibitor of survivin, Mcl-1, XIAP, cIAP2 and MdmX. 2021 2
2 30285798 An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer. 2018 Oct 3 1
3 28337384 Topoisomerase I (Top1): a major target of FL118 for its antitumor efficacy or mainly involved in its side effects of hematopoietic toxicity? 2017 1
4 26692923 FL118, a novel camptothecin analogue, overcomes irinotecan and topotecan resistance in human tumor xenograft models. 2015 1
5 24329001 Antitumor activity of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, is highly dependent on its primary structure and steric configuration. 2014 Feb 3 3
6 24959385 Anticancer drug FL118 is more than a survivin inhibitor: where is the Achilles' heel of cancer? 2014 1
7 23573360 An intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI). 2013 2
8 23029106 A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity. 2012 2