Lovastatin

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cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







46 Article(s)
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Pub. Year
#Total Relationships
1 33459228 HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview. 2021 1
2 31628882 Interaction potential between clarithromycin and individual statins-A systematic review. 2020 Apr 1
3 32729746 An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins. 2020 Sep 1
4 30808332 Severe rhabdomyolysis-induced acute kidney injury following concomitant use of Genvoya® (EVG/COBI/FTC/TAF) and simvastatin; a case report. 2019 Feb 26 1
5 27967318 Effect of polymorphisms in CYP3A4, PPARA, NR1I2, NFKB1, ABCG2 and SLCO1B1 on the pharmacokinetics of lovastatin in healthy Chinese volunteers. 2017 Jan 2
6 26765458 Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study. 2016 Jan 2
7 27605198 Statin-associated rhabdomyolysis triggered by drug-drug interaction with itraconazole. 2016 Sep 7 1
8 25932626 Co-medication of statins with contraindicated drugs. 2015 3
9 24974574 Effect of thyroid hormone status and concomitant medication on statin induced adverse effects in hyperlipidemic patients. 2014 Jun 1
10 23314529 CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control. 2013 2
11 23703578 Drug-drug interactions between HMG-CoA reductase inhibitors (statins) and antiviral protease inhibitors. 2013 Oct 3
12 24256019 [Hypolipidemic agents drug interactions: approach to establish and assess its clinical significance. Structured review]. 2013 Nov-Dec 1
13 21820929 [Specific considerations on the prescription and therapeutic interchange of statins]. 2012 Mar-Apr 2
14 22281720 Impact of CYP2D6 polymorphisms on the pharmacokinetics of lovastatin in Chinese subjects. 2012 Jun 1
15 22529023 Statin medication in patients treated with antiepileptic drugs in Norway. 2012 Aug 1
16 20012601 Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects: role of P-glycoprotein inhibition by lovastatin. 2010 Mar 1
17 21105332 [Effect of polymorphisms of cytochrome P450 and apolipoprotein E genes on therapeutic efficacy of statins]. 2010 1
18 19429419 Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells. 2009 May 12 1
19 18302447 Frequency and clinical relevance of drug interactions with lovastatin and simvastatin: an observational database study. 2008 2
20 19149415 Bama miniature pigs (Sus scrofa domestica) as a model for drug evaluation for humans: comparison of in vitro metabolism and in vivo pharmacokinetics of lovastatin. 2008 Dec 1
21 17452418 Esterase inhibition by grapefruit juice flavonoids leading to a new drug interaction. 2007 Jul 1
22 17615423 Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir. 2007 Jul-Aug 1
23 16581325 Statin safety and drug interactions: clinical implications. 2006 Apr 17 2
24 16581329 Statin safety: a systematic review. 2006 Apr 17 4
25 16714062 Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions. 2006 Oct 2
26 16857822 Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. 2006 Jul 15 2
27 17178259 Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. 2006 Dec 2
28 17233196 Lipid lowering inefficacy of high-dose statin therapy due to concurrent use of phenytoin. 2006 Dec 1
29 15679472 Existence of a clinically relevant interaction between clopidogrel and HMG-CoA reductase inhibitors? Re-evaluating the evidence. 2005 Feb 1
30 14522569 Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study. 2003 Oct 1
31 12433810 Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. 2002 Dec 1
32 12505310 Receptor-dependent regulation of the CYP3A4 gene. 2002 Dec 27 1
33 14727985 Management of protease inhibitor-associated hyperlipidemia. 2002 1
34 11197581 Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin. 2001 Jan 1
35 11475198 [Metabolic interactions with statins]. 2001 Jan 20 1
36 11584328 Treatment of the elderly with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors: focus on drug interactions. 2001 Jul 1
37 11005703 Comparative tolerability of the HMG-CoA reductase inhibitors. 2000 Sep 1
38 11029845 HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles. 2000 Sep-Oct 1
39 11126989 [Undesirable drug interactions of hypolipemic drugs]. 2000 Sep 1
40 33237691 Lipid and Lipoprotein Levels in Patients with COVID-19 Infections 2000 1
41 9929499 Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. 1999 Feb 2
42 10548883 The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways. 1999 1
43 10665838 New insights into the pharmacodynamic and pharmacokinetic properties of statins. 1999 Dec 1
44 9129558 Itraconazole greatly increases plasma concentrations and effects of felodipine. 1997 Apr 1
45 9421099 Itraconazole decreases renal clearance of digoxin. 1997 Dec 1
46 8689812 Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid. 1996 Jul 3