Voriconazole

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







69 Article(s)
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1 35081606 Effects of CYP2C19, CYP2C9 and CYP3A4 gene polymorphisms on plasma voriconazole levels in Chinese pediatric patients. 2022 Jun 1 4
2 35396676 Interactions with the CYP3A inhibitor voriconazole differ between extended-LCP- and immediate-release tacrolimus formulations. 2022 Jun 1
3 35589097 Simultaneous Determination of Cortisol and 6β-Hydroxycortisol in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry. 2022 May 20 1
4 33815119 Application of a Physiologically Based Pharmacokinetic Model to Characterize Time-dependent Metabolism of Voriconazole in Children and Support Dose Optimization. 2021 1
5 33826998 Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants. 2021 Jun 1
6 33971831 Severe secondary hyperkalemia and arrhythmia from drug interactions between calcium-channel blocker and voriconazole: a case presentation. 2021 May 10 1
7 34069798 Pharmacokinetic Drug Interaction between Tofacitinib and Voriconazole in Rats. 2021 May 18 2
8 34402388 Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies. 2021 Oct 8
9 31853755 A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions. 2020 Jun 8
10 32427354 A Novel Study Design Using Continuous Intravenous and Intraduodenal Infusions of Midazolam and Voriconazole for Mechanistic Quantitative Assessment of Hepatic and Intestinal CYP3A Inhibition. 2020 Sep 1
11 33004392 Randomised multicentre clinical trial to evaluate voriconazole pre-emptive genotyping strategy in patients with risk of aspergillosis: vorigenipharm study protocol. 2020 Oct 1 1
12 33124772 Impact of CYP2C19, CYP3A4, ABCB1, and FMO3 genotypes on plasma voriconazole in Thai patients with invasive fungal infections. 2020 Dec 1
13 30572203 Development and validation of a volumetric absorptive microsampling assay for analysis of voriconazole and voriconazole N-oxide in human whole blood. 2019 Jan 15 1
14 31152598 Prolonged-Release Tacrolimus Is Less Susceptible to Interaction With the Strong CYP3A Inhibitor Voriconazole in Healthy Volunteers. 2019 Dec 2
15 28786218 Response to "Impact of CYP3A4 Genotype on Voriconazole Exposure: New Insights Into the Contribution of CYP3A4*22 to Metabolism of Voriconazole". 2018 Feb 4
16 28786228 Impact of CYP3A4 Genotype on Voriconazole Exposure. 2018 Feb 1
17 29055041 The possible clinical impact of risperidone on P-glycoprotein-mediated transport of tacrolimus: A case report and in vitro study. 2018 Jan 1
18 30167757 Voriconazole greatly increases the exposure to oral buprenorphine. 2018 Dec 2
19 27432796 CYP2C19 Genotype-Dependent Pharmacokinetic Drug Interaction Between Voriconazole and Ritonavir-Boosted Atazanavir in Healthy Subjects. 2017 Feb 1
20 27822915 Analysis of the variable factors influencing tacrolimus blood concentration during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation. 2017 Mar 1
21 27937048 Effects of cytochrome P450 3A4 and non-genetic factors on initial voriconazole serum trough concentrations in hematological patients with different cytochrome P450 2C19 genotypes. 2017 Dec 2
22 28182291 Pharmacogenetics of Voriconazole: CYP2C19 but Also CYP3A4 Need to Be Genotyped. 2017 Aug 1
23 28370390 Autoinhibitory properties of the parent but not of the N-oxide metabolite contribute to infusion rate-dependent voriconazole pharmacokinetics. 2017 Sep 3
24 28455946 Response to "Pharmacogenetics of Voriconazole: CYP2C19 but Also CYP3A4 Need to Be Genotyped" - The Role of CYP3A4 and CYP3A5 Polymorphisms in Clinical Pharmacokinetics of Voriconazole. 2017 Aug 2
25 28674358 Acute Kidney Injury from Excessive Potentiation of Calcium-channel Blocker via Synergistic CYP3A4 Inhibition by Clarithromycin Plus Voriconazole. 2017 2
26 26502771 Voriconazole-Induced Hepatitis via Simvastatin- and Lansoprazole-Mediated Drug Interactions: A Case Report and Review of the Literature. 2016 Jan 1
27 27236320 Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole. 2016 Dec 3
28 25417855 Worsening pneumonitis due to a pharmacokinetic drug-drug interaction between everolimus and voriconazole in a renal transplant patient. 2015 Feb 1
29 25515945 Effects of CYP3A4 polymorphisms on the plasma concentration of voriconazole. 2015 Apr 6
30 25599164 Safety of voriconazole and sirolimus coadministration after allogeneic hematopoietic SCT. 2015 Mar 1
31 25868557 Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism. 2015 Jun 2
32 24757038 Iatrogenic cushing syndrome secondary to a probable interaction between voriconazole and budesonide. 2014 Jul 2
33 25120580 Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity. 2014 1
34 25429674 Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450. 2014 4
35 23653047 A semiphysiological population pharmacokinetic model for dynamic inhibition of liver and gut wall cytochrome P450 3A by voriconazole. 2013 Sep 2
36 23766489 Steady-state pharmacokinetics and metabolism of voriconazole in patients. 2013 Nov 1
37 22106961 Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes. 2012 May 4
38 22381043 Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine. 2012 Nov 1
39 21937987 Determining the time course of CYP3A inhibition by potent reversible and irreversible CYP3A inhibitors using A limited sampling strategy. 2011 Nov 1
40 19841059 In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3. 2010 Jan 1
41 19898510 Pharmacokinetics of CsA during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation. 2010 Jun 1
42 20175821 Effects of voriconazole on tacrolimus metabolism in a kidney transplant recipient. 2010 Feb 1
43 20642349 Pharmacokinetic variability of voriconazole and N-oxide voriconazole measured as therapeutic drug monitoring. 2010 Oct 2
44 20669013 Effects of erythromycin on voriconazole pharmacokinetics and association with CYP2C19 polymorphism. 2010 Nov 2
45 18777173 Oral voriconazole and miconazole oral gel produce comparable effects on the pharmacokinetics and pharmacodynamics of etoricoxib. 2009 Jan 1
46 18836708 Voriconazole drastically increases exposure to oral oxycodone. 2009 Mar 1
47 19029318 Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A. 2009 Feb 5
48 19033450 CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole. 2009 Feb 1
49 19916995 Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole. 2009 Nov 1
50 20002085 Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype. 2009 Dec 1