Bortezomib

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







13 Article(s)
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Pub. Year
#Total Relationships
1 32291610 A Translational Physiologically Based Pharmacokinetics/Pharmacodynamics Framework of Target-Mediated Disposition, Target Inhibition and Drug-Drug Interactions of Bortezomib. 2020 Apr 14 1
2 29802543 Clinical Pharmacokinetics and Pharmacodynamics of Bortezomib. 2019 Feb 4
3 27325500 Bortezomib and ixazomib protect firefly luciferase from degradation and can flaw respective reporter gene assays. 2016 Sep 15 2
4 25915157 Human bone marrow niche chemoprotection mediated by cytochrome P450 enzymes. 2015 Jun 20 1
5 26622646 Effect of CYP2C19 and CYP3A4 gene polymorphisms on the efficacy of bortezomib-based regimens in patients with multiple myeloma. 2015 Aug 1
6 22087865 Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or non-Hodgkin's lymphoma. 2011 Dec 1 2
7 20575631 Drug interaction between itraconazole and bortezomib: exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib. 2010 Jul 4
8 20837660 Metabolism and action of proteasome inhibitors in primary human hepatocytes. 2010 Dec 1
9 20110052 Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: a prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study. 2009 3
10 16489083 Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors. 2006 Feb 15 4
11 16764098 Bortezomib: new indication. Second-line treatment of myeloma: limited efficacy, major risks. 2006 Jun 1
12 15764713 Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites. 2005 Jun 1
13 16103134 Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib. 2005 Nov 2