Gemfibrozil

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







10 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 28479356 Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data. 2017 Sep 1
2 20208386 System-dependent outcomes during the evaluation of drug candidates as inhibitors of cytochrome P450 (CYP) and uridine diphosphate glucuronosyltransferase (UGT) enzymes: human hepatocytes versus liver microsomes versus recombinant enzymes. 2010 1
3 15771232 Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes. 2005 Jan 1
4 16042675 Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide. 2005 Aug 2
5 16283275 Effect of gemfibrozil on the pharmacokinetics of pioglitazone. 2005 Dec 1
6 15194707 Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. 2004 Oct 1
7 14682608 Interaction between fibrates and statins--metabolic interactions with gemfibrozil. 2003 1
8 12023536 Mechanistic studies on metabolic interactions between gemfibrozil and statins. 2002 Jun 3
9 12386136 Effects of fibrates on metabolism of statins in human hepatocytes. 2002 Nov 3
10 12433802 Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. 2002 Dec 1