| 1 |
32967779 | Applications of a grid-based CYP3A4 Template system to understand the interacting mechanisms of large-size ligands; part 4 of CYP3A4 Template study. | 2020 Dec |
1 |
| 2 |
30390556 | Study on the inhibitory effect of furafylline and troleandomycin in the 7-methoxyresorufin-O-demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescence and ultraviolet detection. | 2019 Feb 5 |
2 |
| 3 |
29785610 | Evaluation of Strategies for the Assessment of Drug-Drug Interactions Involving Cytochrome P450 Enzymes. | 2018 Dec |
1 |
| 4 |
26970587 | Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4. | 2016 May |
1 |
| 5 |
24335510 | Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system. | 2014 Mar |
1 |
| 6 |
24889073 | Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. | 2014 Aug |
2 |
| 7 |
20876785 | In vitro cytochrome P450-mediated metabolism of exemestane. | 2011 Jan |
1 |
| 8 |
21576599 | Cholesterol 25-hydroxylation activity of CYP3A. | 2011 Aug |
1 |
| 9 |
21622627 | In vitro metabolism of the mycotoxin enniatin B in different species and cytochrome p450 enzyme phenotyping by chemical inhibitors. | 2011 Sep |
1 |
| 10 |
19293388 | As in humans, pregnancy increases the clearance of the protease inhibitor nelfinavir in the nonhuman primate Macaca nemestrina. | 2009 Jun |
1 |
| 11 |
19307295 | Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells. | 2009 Jun |
2 |
| 12 |
19616568 | Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes. | 2009 Nov 15 |
1 |
| 13 |
18505790 | A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine. | 2008 Aug |
1 |
| 14 |
18573861 | Identification of enzymes involved in the metabolism of 17alpha-hydroxyprogesterone caproate: an effective agent for prevention of preterm birth. | 2008 Sep |
1 |
| 15 |
19149415 | Bama miniature pigs (Sus scrofa domestica) as a model for drug evaluation for humans: comparison of in vitro metabolism and in vivo pharmacokinetics of lovastatin. | 2008 Dec |
1 |
| 16 |
17207564 | Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. | 2007 May |
1 |
| 17 |
16416302 | Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate. | 2006 Mar |
1 |
| 18 |
16679385 | Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes. | 2006 Aug |
1 |
| 19 |
15546903 | CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. | 2005 Feb |
2 |
| 20 |
15557344 | Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. | 2005 Mar |
1 |
| 21 |
15746066 | Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes. | 2005 Feb 15 |
1 |
| 22 |
15764719 | Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator. | 2005 Jun |
1 |
| 23 |
14678348 | Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity. | 2004 Jan |
1 |
| 24 |
15005856 | CYP3A4 is a human microsomal vitamin D 25-hydroxylase. | 2004 Apr |
2 |
| 25 |
15054565 | Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro. | 2004 May |
1 |
| 26 |
15184267 | Relationship between content and activity of cytochrome P450 and induction of heterocyclic amine DNA adducts in human liver samples in vivo and in vitro. | 2004 Jun |
1 |
| 27 |
15268978 | Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone. | 2004 Apr |
1 |
| 28 |
15356306 | Oral erythromycin and the risk of sudden death from cardiac causes. | 2004 Sep 9 |
2 |
| 29 |
12848784 | The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6. | 2003 Jul |
1 |
| 30 |
12936704 | Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes. | 2003 Aug |
1 |
| 31 |
14652237 | Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. | 2003 Dec 3 |
1 |
| 32 |
15618724 | CYP isoforms involved in the metabolism of clarithromycin in vitro: comparison between the identification from disappearance rate and that from formation rate of metabolites. | 2003 |
1 |
| 33 |
11752104 | O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes. | 2002 Jan |
1 |
| 34 |
12160484 | Metabolism of a novel phosphodiesterase-IV inhibitor (V11294) by human hepatic cytochrome P450 forms. | 2002 Jun |
1 |
| 35 |
12162853 | Involvement of cytochrome P450 in the metabolism of rebamipide by the human liver. | 2002 Jul |
1 |
| 36 |
12180536 | The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. | 2002 Jul |
1 |
| 37 |
12433801 | Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5. | 2002 Dec |
1 |
| 38 |
15618694 | Species difference in nisoldipine oxidation activity in the small intestine. | 2002 |
1 |
| 39 |
11259570 | Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. | 2001 Apr |
1 |
| 40 |
11259984 | Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. | 2001 Feb |
1 |
| 41 |
11409940 | Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes. | 2001 Jun |
2 |
| 42 |
11428655 | Nefiracetam metabolism by human liver microsomes: role of cytochrome P450 3A4 and cytochrome P450 1A2 in 5-hydroxynefiracetam formation. | 2001 Jun |
1 |
| 43 |
11454734 | Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. | 2001 Aug |
1 |
| 44 |
11504799 | Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. | 2001 Sep |
1 |
| 45 |
11730569 | Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes. | 2001 Jan |
1 |
| 46 |
11741520 | Role of cytochrome P450 in estradiol metabolism in vitro. | 2001 Feb |
1 |
| 47 |
10692561 | Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. | 2000 Apr 15 |
1 |
| 48 |
10725304 | Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A. | 2000 Apr |
1 |
| 49 |
10901707 | Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. | 2000 Aug |
1 |
| 50 |
10923859 | Identification of enzymes responsible for rifalazil metabolism in human liver microsomes. | 2000 Jun |
3 |