| 1 |
34035488 | Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes. | 2022 Mar |
2 |
| 2 |
34267345 | Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers. | 2022 Apr |
2 |
| 3 |
34623637 | Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil. | 2022 Feb |
1 |
| 4 |
34949673 | Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 Are Involved in Ritonavir-Induced Cytotoxicity in Hepatoma Cells. | 2022 May |
1 |
| 5 |
35165925 | Acalabrutinib CYP3A-mediated drug-drug interactions: Clinical evaluations and physiologically based pharmacokinetic modelling to inform dose adjustment strategy. | 2022 Feb 15 |
1 |
| 6 |
35230741 | A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors. | 2022 Mar 1 |
1 |
| 7 |
35238961 | Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans. | 2022 Jun |
1 |
| 8 |
35428895 | Assessment of cytochrome P450 3A4-mediated drug-drug interactions for ipatasertib using a fit-for-purpose physiologically based pharmacokinetic model. | 2022 May |
1 |
| 9 |
35435627 | Effects of rifampicin on antineoplastic drug pyrotinib maleate pharmacokinetics in healthy subjects. | 2022 Apr 18 |
2 |
| 10 |
35506332 | Evaluation of drug-drug interaction potential for pemigatinib using physiologically based pharmacokinetic modeling. | 2022 May 4 |
1 |
| 11 |
35510231 | Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells. | 2022 Apr |
1 |
| 12 |
35569070 | Long-term efficacy and safety of rifampin in the treatment of a patient carrying a CYP24A1 loss-of-function variant. | 2022 May 15 |
2 |
| 13 |
35579824 | Prediction of Drug-Drug Interactions After Esketamine Intranasal Administration Using a Physiologically Based Pharmacokinetic Model. | 2022 May 17 |
1 |
| 14 |
35605912 | Effects of itraconazole and rifampicin on the pharmacokinetics and safety of youkenafil, a novel phosphodiesterase type 5 inhibitor, in healthy Chinese subjects. | 2022 May 20 |
1 |
| 15 |
35616006 | Pharmacokinetics of asciminib in the presence of CYP3A or P-gp inhibitors, CYP3A inducers, and acid-reducing agents. | 2022 May 26 |
1 |
| 16 |
32705692 | A Microdose Cocktail to Evaluate Drug Interactions in Patients with Renal Impairment. | 2021 Feb |
2 |
| 17 |
32990533 | Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China. | 2021 |
2 |
| 18 |
33155329 | Levofloxacin based non-rifampicin anti-tuberculous therapy: An effective alternative in renal transplant recipients in resource limited setting. | 2021 Feb |
1 |
| 19 |
33263786 | Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells. | 2021 Mar |
1 |
| 20 |
33355212 | Evaluation of Tissue Stem Cell-Derived Human Intestinal Organoids, a Physiologically Relevant Model to Evaluate Cytochrome P450 Induction in Gut. | 2021 Mar |
2 |
| 21 |
33483427 | Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor. | 2021 Mar |
1 |
| 22 |
33506323 | Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers. | 2021 Aug |
2 |
| 23 |
33590212 | Micropatterned Coculture With 3T3-J2 Fibroblasts Enhances Hepatic Functions and Drug Screening Utility of HepaRG Cells. | 2021 Apr 27 |
1 |
| 24 |
33672438 | The 1β-Hydroxy-Deoxycholic Acid to Deoxycholic Acid Urinary Metabolic Ratio: Toward a Phenotyping of CYP3A Using an Endogenous Marker? | 2021 Feb 20 |
1 |
| 25 |
33863817 | Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction. | 2021 Jul |
1 |
| 26 |
33963620 | Concomitant use of isavuconazole and CYP3A4/5 inducers: Where pharmacogenetics meets pharmacokinetics. | 2021 Sep |
2 |
| 27 |
34069974 | Effect of Vitamin K-Mediated PXR Activation on Drug-Metabolizing Gene Expression in Human Intestinal Carcinoma LS180 Cell Line. | 2021 May 18 |
1 |
| 28 |
34145979 | Effects of Itraconazole and Rifampin on the Pharmacokinetics of Mobocertinib (TAK-788), an Oral Epidermal Growth Factor Receptor Inhibitor, in Healthy Volunteers. | 2021 Sep |
1 |
| 29 |
34273250 | Prediction of the drug-drug interaction potential of the α1-acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib. | 2021 Sep |
1 |
| 30 |
34282472 | Evaluation of drug-drug interactions of pemigatinib in healthy participants. | 2021 Dec |
1 |
| 31 |
34345857 | Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR. | 2021 |
1 |
| 32 |
34664792 | In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor. | 2021 Dec |
1 |
| 33 |
34729944 | Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P-glycoprotein-cytochrome P450 3A4 dual substrates. | 2021 Dec |
4 |
| 34 |
34762904 | Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine. | 2021 Dec 15 |
1 |
| 35 |
34872459 | Study on the associations between liver damage and antituberculosis drug rifampicin and relative metabolic enzyme gene polymorphisms. | 2021 Dec |
1 |
| 36 |
31432507 | Long-term maintenance of functional primary human hepatocytes using small molecules. | 2020 Jan |
1 |
| 37 |
31863284 | The Effect of Rifampin on the Pharmacokinetics and Safety of Lorlatinib: Results of a Phase One, Open-Label, Crossover Study in Healthy Participants. | 2020 Feb |
1 |
| 38 |
31877331 | Epigenetic sensitization of pregnane X receptor-regulated gene expression by dimethyl sulfoxide. | 2020 Mar 15 |
1 |
| 39 |
31884012 | Successful Prediction of Human Pharmacokinetics After Oral Administration by Optimized Physiologically Based Pharmacokinetics Approach and Permeation Assay Using Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells. | 2020 Apr |
2 |
| 40 |
31993325 | Effects of paroxetine, ketoconazole, and rifampin on the metabolism of eliglustat, an oral substrate reduction therapy for Gaucher disease type 1. | 2020 Mar |
3 |
| 41 |
32235864 | Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. | 2020 Oct |
2 |
| 42 |
32250463 | Effects of itraconazole and rifampicin on the single-dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects. | 2020 Oct |
1 |
| 43 |
32275771 | The Effects of Weak and Strong CYP3A Induction by Rifampicin on the Pharmacokinetics of Five Progestins and Ethinylestradiol Compared to Midazolam. | 2020 Oct |
2 |
| 44 |
32291610 | A Translational Physiologically Based Pharmacokinetics/Pharmacodynamics Framework of Target-Mediated Disposition, Target Inhibition and Drug-Drug Interactions of Bortezomib. | 2020 Apr 14 |
1 |
| 45 |
32320483 | Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes. | 2020 Oct |
1 |
| 46 |
32350061 | Enrichment-free High-throughput Liquid Chromatography-Multiple-Reaction Monitoring Quantification of Cytochrome P450 Proteins in Plated Human Hepatocytes Direct from 96-Well Plates Enables Routine Protein Induction Measurements. | 2020 Jul |
1 |
| 47 |
32407272 | Influence of Rifampicin Pre-treatment on the In vivo Pharmacokinetics of Metoclopramide in Pakistani Healthy Volunteers Following Concurrent Oral Administration. | 2020 |
1 |
| 48 |
32557601 | Ribociclib Drug-Drug Interactions: Clinical Evaluations and Physiologically-Based Pharmacokinetic Modeling to Guide Drug Labeling. | 2020 Sep |
1 |
| 49 |
32788213 | Nuclear receptor phosphorylation in xenobiotic signal transduction. | 2020 Nov 6 |
1 |
| 50 |
32918434 | Resistant hypertension during antituberculosis treatment: how is rifampicin implicated? | 2020 Sep |
1 |