Caffeine

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







18 Article(s)
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1 31744669 Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research. 2020 Feb 5 1
2 32050158 An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma. 2020 Mar 1 1
3 32279279 The atypical neuroleptics iloperidone and lurasidone inhibit human cytochrome P450 enzymes in vitro. Evaluation of potential metabolic interactions. 2020 Dec 1
4 31123759 Identification of the caffeine to trimethyluric acid ratio as a dietary biomarker to characterise variability in cytochrome P450 3A activity. 2019 Sep 3
5 29063606 Harnessing Meta-analysis to Refine an Oncology Patient Population for Physiology-Based Pharmacokinetic Modeling of Drugs. 2018 Feb 1
6 27127017 The CYTONOX trial. 2016 May 1
7 23682612 The effect of organic solvents on enzyme kinetic parameters of human CYP3A4 and CYP1A2 in vitro. 2013 Oct 1
8 22725721 A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4. 2012 Nov 1
9 20716633 Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. 2010 Sep 1
10 20924570 Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women. 2010 Dec 1
11 20002088 Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A. 2009 Dec 1
12 15997229 Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula. 2005 Sep 1
13 12376329 Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans. 2002 Nov 1
14 10634135 Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine. 1999 Dec 3
15 9868741 Fluvoxamine is a potent inhibitor of the metabolism of caffeine in vitro. 1998 Dec 2
16 10076532 Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats. 1998 May 1 1
17 9390105 Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivo inhibition constants. 1997 Nov 1
18 8930576 Metabolic interactions of the proton-pump inhibitors lansoprazole, omeprazole and pantoprazole with other drugs. 1996 Oct 1