Clozapine

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







31 Article(s)
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1 32386926 Unusually high serum levels of clozapine associated with genetic polymorphism of CYP3A enzymes. 2021 Mar 1
2 32888176 Levomepromazine and clozapine induce the main human cytochrome P450 drug metabolizing enzyme CYP3A4. 2021 Feb 6
3 32103962 The CYP2C19*2 and CYP2C19*17 Polymorphisms Influence Responses to Clozapine for the Treatment of Schizophrenia. 2020 2
4 33277605 Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia. 2020 Dec 4 8
5 29155491 Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors. 2018 Apr 3
6 28340122 Potential Role of Patients' CYP3A-Status in Clozapine Pharmacokinetics. 2017 Jul 1 9
7 27164071 In Vitro Effects of Concomitant Use of Herbal Preparations on Cytochrome P450s Involved in Clozapine Metabolism. 2016 May 6 1
8 23297297 Characterization of human cytochrome P450s involved in the bioactivation of clozapine. 2013 Mar 2
9 22113252 Interaction of St John's wort (Hypericum perforatum) with clozapine. 2012 Mar 1
10 28520368 Clozapine Therapy and CYP Genotype 2012 2
11 19593168 ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine. 2009 Aug 1
12 19801957 The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test. 2009 Nov 1
13 19843060 In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation. 2009 Oct 1
14 18537577 Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. 2008 Jun 1
15 18809730 Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. 2008 Dec 2
16 17392390 Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process. 2007 Jul 1
17 17504220 CYP-mediated clozapine interactions: how predictable are they? 2007 May 1
18 16184070 Examining concentration-dependent toxicity of clozapine: role of therapeutic drug monitoring. 2005 Sep 2
19 12665390 Fatalities associated with therapeutic use and overdose of atypical antipsychotics. 2003 1
20 12670127 Interactions between the cytochrome P450 system and the second-generation antipsychotics. 2003 Mar 1
21 11504269 Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations. 2001 Aug 1
22 10359460 Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine. 1999 Apr 1 1
23 10365650 Small effects of valproic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders. 1999 Jun 1
24 10379638 Absence of interaction between erythromycin and a single dose of clozapine. 1999 May 2
25 10422890 Drug metabolism and atypical antipsychotics. 1999 Jun 2
26 10435773 The effect of nefazodone on clozapine plasma concentrations. 1999 May 2
27 9626923 Serum concentrations of clozapine and N-desmethylclozapine are unaffected by the potent CYP3A4 inhibitor itraconazole. 1998 Apr 3
28 9840430 Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine. 1998 Nov 3
29 9384460 The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. 1997 Nov 4
30 8866916 In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A. 1996 Mar 1
31 7974626 Fluvoxamine inhibition and carbamazepine induction of the metabolism of clozapine: evidence from a therapeutic drug monitoring service. 1994 Aug 1