sapropterin

sepiapterin reductase ; Mus musculus







24 Article(s)
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1 35192730 Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice. 2022 May 5
2 31350812 Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice. 2020 Jan 1
3 32541389 Peripheral tetrahydrobiopterin is involved in the pathogenesis of mechanical hypersensitivity in a rodent postsurgical pain model. 2020 Nov 1
4 31381993 Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. 2019 Nov 1 1
5 30405245 The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. 2018 Nov 2
6 28320892 Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia. 2017 Mar 2
7 23577163 Amelioration of behavioral abnormalities in BH(4)-deficient mice by dietary supplementation of tyrosine. 2013 3
8 23640889 Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. 2013 Jun 28 2
9 23933678 Increase in tetrahydrobiopterin concentration with aging in the cerebral cortex of the senescence-accelerated mouse prone 10 strain caused by abnormal regulation of tetrahydrobiopterin biosynthesis. 2013 Oct 4
10 21795851 Autophagy induction by tetrahydrobiopterin deficiency. 2011 Nov 1
11 20846490 Alterations in dopamine and glutamate neurotransmission in tetrahydrobiopterin deficient spr-/- mice: relevance to schizophrenia. 2010 Sep 1
12 19429835 Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. 2009 Jul 9
13 19767531 eNOS uncoupling and endothelial dysfunction in aged vessels. 2009 Nov 3
14 18201550 A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease. 2008 Mar 21 7
15 18542834 Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin. 2008 Jun 2
16 16532389 A murine model for human sepiapterin-reductase deficiency. 2006 Apr 2
17 12535931 Peripheral administration of lipopolysaccharide enhances the expression of guanosine triphosphate cyclohydrolase I mRNA in murine locus coeruleus. 2003 1
18 10350607 Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase. 1999 May 18 4
19 9405351 The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. 1997 Dec 15 1
20 8549660 Effects of depletion of intracellular tetrahydrobiopterin in murine erythroleukemia cells. 1996 Jan 10 1
21 7873607 Mouse sepiapterin reductase: an enzyme involved in the final step of tetrahydrobiopterin biosynthesis. Primary structure deduced from the cDNA sequence. 1995 Feb 21 2
22 7510954 Nitric oxide production depends on preceding tetrahydrobiopterin synthesis by endothelial cells: selective suppression of induced nitric oxide production by sepiapterin reductase inhibitors. 1994 Mar 15 2
23 7678692 Tetrahydrobiopterin is required for cytokine-induced nitric oxide production in a murine macrophage cell line (RAW 264). 1993 Jan 1
24 1764035 Impact of tumour necrosis factor-alpha and interferon-gamma on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages. 1991 Dec 15 1