2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide

mitogen-activated protein kinase 1 ; Homo sapiens







23 Article(s)
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1 30256438 MAPK/ERK pathway inhibition is a promising treatment target for adrenocortical tumors. 2019 Jan 1
2 31077745 Prodigiosin induces apoptosis and inhibits autophagy via the extracellular signal-regulated kinase pathway in K562 cells. 2019 Oct 1
3 29330049 The histone demethylase PHF8 promotes adult acute lymphoblastic leukemia through interaction with the MEK/ERK signaling pathway. 2018 Feb 12 2
4 30647839 MEK-inhibitor PD184352 enhances the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922: the role of cell type and drug-irradiation schedule. 2018 Dec 21 1
5 26953171 Epidermal Growth Factor Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells. 2016 May 1
6 26526356 A Her2-let-7-β2-AR circuit affects prognosis in patients with Her2-positive breast cancer. 2015 Nov 2 1
7 23813779 Tanshinone IIA induces autophagic cell death via activation of AMPK and ERK and inhibition of mTOR and p70 S6K in KBM-5 leukemia cells. 2014 Mar 1
8 24445144 The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival. 2014 Jul 1
9 24916153 Central role for protein kinase C in oxytocin and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells. 2014 Jun 10 2
10 23804705 Pharmacologic inhibition of MEK signaling prevents growth of canine hemangiosarcoma. 2013 Sep 1
11 23876460 Cadmium induces N-cadherin cleavage via ERK-mediated γ-secretase activation in C6 astroglia cells. 2013 Oct 24 1
12 24019880 FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues. 2013 1
13 21483442 The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells. 2011 Jul 1
14 19149686 Recent developments in anti-cancer agents targeting the Ras/Raf/ MEK/ERK pathway. 2009 Jan 1
15 19737956 Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma. 2009 Sep 15 3
16 18211802 ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA. 2008 Mar 28 1
17 16848763 Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ. 2006 Oct 15 1
18 15381709 Characterization of the MEK5-ERK5 module in human neutrophils and its relationship to ERK1/ERK2 in the chemotactic response. 2004 Nov 26 2
19 12727228 Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44. 2003 May 16 2
20 14566055 Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. 2003 Oct 28 2
21 14613031 CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). 2003 Oct 2
22 11478941 Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway. 2001 Jul 27 1
23 11728381 Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor beta and mitogen-activated protein kinases. 2001 Dec 1 2