Paclitaxel

mitogen-activated protein kinase 1 ; Homo sapiens







82 Article(s)
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1 33788730 Effect of Metformin in Combination With Trametinib and Paclitaxel on Cell Survival and Metastasis in Melanoma Cells. 2021 Mar 3
2 34000456 Integrating transcriptomics, proteomics, glycomics and glycoproteomics to characterize paclitaxel resistance in breast cancer cells. 2021 Jul 15 1
3 34370483 ERK-Peptide-Inhibitor-Modified Ferritin Enhanced the Therapeutic Effects of Paclitaxel in Cancer Cells and Spheroids. 2021 Sep 6 1
4 34512368 Targeting Autophagy with Natural Compounds in Cancer: A Renewed Perspective from Molecular Mechanisms to Targeted Therapy. 2021 1
5 34685613 7-Epitaxol Induces Apoptosis and Autophagy in Head and Neck Squamous Cell Carcinoma through Inhibition of the ERK Pathway. 2021 Oct 2 1
6 31783010 Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin. 2020 Jan 1
7 32547883 Ginsenoside panaxatriol reverses TNBC paclitaxel resistance by inhibiting the IRAK1/NF-κB and ERK pathways. 2020 1
8 32594651 Paclitaxel induces apoptosis through the TAK1-JNK activation pathway. 2020 Aug 1
9 33256016 Sitagliptin Modulates the Response of Ovarian Cancer Cells to Chemotherapeutic Agents. 2020 Nov 26 1
10 30810041 Plumbagin Increases Paclitaxel-Induced Cell Death and Overcomes Paclitaxel Resistance in Breast Cancer Cells through ERK-Mediated Apoptosis Induction. 2019 Apr 26 5
11 30866433 Histone Deacetylase Inhibitor, Trichostatin A, Synergistically Enhances Paclitaxel-Induced Cytotoxicity in Urothelial Carcinoma Cells by Suppressing the ERK Pathway. 2019 Mar 7 1
12 30866697 Dasatinib can enhance paclitaxel and gemcitabine inhibitory activity in human pancreatic cancer cells. 2019 1
13 31031868 Inhibition of RNA-Binding Protein Musashi-1 Suppresses Malignant Properties and Reverses Paclitaxel Resistance in Ovarian Carcinoma. 2019 1
14 31114158 Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo. 2019 1
15 31321352 Synergistic Enhancement of Paclitaxel-induced Inhibition of Cell Growth by Metformin in Melanoma Cells. 2019 Jun 2
16 31334335 FoxM1 Induced Paclitaxel Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter. 2019 Sep 27 2
17 31570440 Apatinib Reverses Paclitaxel-resistant Lung Cancer Cells (A549) Through Blocking the Function of ABCB1 Transporter. 2019 Oct 1
18 28766096 Inhibiting ERK/Mnk/eIF4E broadly sensitizes ovarian cancer response to chemotherapy. 2018 Mar 1
19 29435178 Inhibition of the MEK/ERK pathway augments nab-paclitaxel-based chemotherapy effects in preclinical models of pancreatic cancer. 2018 Jan 12 1
20 29693189 Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation. 2018 Jun 2
21 30221728 Combination of pristimerin and paclitaxel additively induces autophagy in human breast cancer cells via ERK1/2 regulation. 2018 Nov 3
22 28849180 Silencing Aurora A leads to re-sensitization of breast cancer cells to Taxol through downregulation of SRC-mediated ERK and mTOR pathways. 2017 Oct 4
23 26810068 GRIM-19 inhibition induced autophagy through activation of ERK and HIF-1α not STAT3 in Hela cells. 2016 Jul 1
24 26881937 Regulation of Oncoprotein 18/Stathmin Signaling by ERK Concerns the Resistance to Taxol in Nonsmall Cell Lung Cancer Cells. 2016 Mar 6
25 27422607 DUSP1 induces paclitaxel resistance through the regulation of p-glycoprotein expression in human ovarian cancer cells. 2016 Sep 9 2
26 25754234 PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples. 2015 May 1
27 25946136 Let-7 Sensitizes KRAS Mutant Tumor Cells to Chemotherapy. 2015 1
28 26375501 Non-adherent culture induces paclitaxel resistance in H460 lung cancer cells via ERK-mediated up-regulation of βIVa-tubulin. 2015 Oct 23 3
29 24080340 Identification and analysis of CD133(+) melanoma stem-like cells conferring resistance to taxol: An insight into the mechanisms of their resistance and response. 2014 Feb 1 4
30 24173825 Caffeine inhibits paclitaxel‑induced apoptosis in colorectal cancer cells through the upregulation of Mcl‑1 levels. 2014 Jan 2
31 24729449 Targeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer. 2014 Jun 1
32 24817940 AKT/ERK activation is associated with gastric cancer cell resistance to paclitaxel. 2014 3
33 23735541 Apoptosis induced by paclitaxel via Bcl-2, Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition. 2013 Nov 1
34 23879997 [Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway]. 2013 Mar 2
35 24024333 Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells. 2013 Jun 1
36 24137360 Synergy of Taxol and rhein lysinate associated with the downregulation of ERK activation in lung carcinoma cells. 2013 Aug 3
37 22743248 Icariside II potentiates paclitaxel-induced apoptosis in human melanoma A375 cells by inhibiting TLR4 signaling pathway. 2012 Sep 4
38 24212635 Ras Isoprenylation and pAkt Inhibition by Zoledronic Acid and Fluvastatin Enhances Paclitaxel Activity in T24 Bladder Cancer Cells. 2011 Feb 14 1
39 20068074 Secretory leukocyte protease inhibitor antagonizes paclitaxel in ovarian cancer cells. 2010 Jan 15 2
40 20726858 Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer. 2010 Nov 1
41 19048624 Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer. 2009 Mar 15 6
42 19521235 Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78. 2009 Aug 2
43 19619321 KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells. 2009 Jul 20 2
44 19717209 Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells. 2009 Dec 2
45 18068334 Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2. 2008 Feb 3
46 18256541 Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells. 2008 Mar 1 1
47 18272284 Hypoxia-inducible transcription factor (HIF)-1 alpha stabilization by actin-sequestering protein, thymosin beta-4 (TB4) in Hela cervical tumor cells. 2008 Jun 8 1
48 18676833 Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. 2008 Aug 1 2
49 17012370 Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction. 2007 Feb 1
50 17143528 Dexamethasone inhibits paclitaxel-induced cytotoxic activity through retinoblastoma protein dephosphorylation in non-small cell lung cancer cells. 2007 Jan 1