17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

heat shock protein 90 alpha family class A member 1 ; Homo sapiens







116 Article(s)
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1 34820556 Near-infrared light triggered multi-hit therapeutic nanosystem for tumor specific photothermal effect amplified signal pathway regulation and ferroptosis. 2022 Mar 4
2 35327426 Different HSP90 Inhibitors Exert Divergent Effect on Myxoid Liposarcoma In Vitro and In Vivo. 2022 Mar 7 1
3 33416122 Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17‑DMAG and ganetespib on tumor cells. 2021 Feb 1
4 34055735 Development and Characterization of PLGA Nanoparticles Containing 17-DMAG, an Hsp90 Inhibitor. 2021 7
5 34200311 Inhibition of Hsp90 Counteracts the Established Experimental Dermal Fibrosis Induced by Bleomycin. 2021 Jun 7 2
6 34956178 A Novel Role for the Regulatory Nod-Like Receptor NLRP12 in Anti-Dengue Virus Response. 2021 1
7 31726100 Destabilization of ROR1 enhances activity of Ibrutinib against chronic lymphocytic leukemia in vivo. 2020 Jan 1
8 32151689 17-DMAG disrupted the autophagy flux leading to the apoptosis of acute lymphoblastic leukemia cells by inducing heat shock cognate protein 70. 2020 May 15 1
9 32497199 Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells. 2020 Oct 30 1
10 32608202 Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells. 2020 Jul 1
11 30788006 HSP90 inhibitor 17-DMAG effectively alleviated the progress of thoracic aortic dissection by suppressing smooth muscle cell phenotypic switch. 2019 2
12 31611575 A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90. 2019 Oct 14 2
13 29433909 Heat shock protein 90 inhibitor enhances apoptosis by inhibiting the AKT pathway in thermal-stimulated SK-MEL-2 human melanoma cell line. 2018 Jun 1
14 29602128 Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art. 2018 Jun 3
15 30021337 17-DMAG-loaded nanofibrous scaffold for effective growth inhibition of lung cancer cells through targeting HSP90 gene expression. 2018 Sep 5
16 30453475 Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition. 2018 Nov 16 2
17 27600766 Evaluation of the radiosensitizing potency of chemotherapeutic agents in prostate cancer cells. 2017 Feb 1
18 27887849 Inhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(4'fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole in A2780cis cells. 2017 Jan 2
19 28255900 Re-examining HSPC1 inhibitors. 2017 Mar 1
20 28529458 Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer. 2017 1
21 28779264 Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition. 2017 Oct 1
22 28823258 [Proliferation and Apoptosis of Leukemia Cell Line K562 Treated with HSP90 Inhibitor 17-DMAG]. 2017 Aug 3
23 28823260 [Effect of Heat Shock Protein 90 Inhibitor 17-DMAG on Proliferation and Apoptosis of Acute Lymphocytic Leukemia Cell Line Jurkat]. 2017 Aug 2
24 28871086 Identification of HSP90 inhibitors as a novel class of senolytics. 2017 Sep 4 1
25 28914785 Hsp90α Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2. 2017 Sep 15 2
26 28915605 HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance. 2017 Aug 22 2
27 26379118 Organ-specific efficacy of HSP90 inhibitor in multiple-organ metastasis model of chemorefractory small cell lung cancer. 2016 Mar 1 1
28 26662567 17-DMAG induces heat shock protein 90 functional impairment in human bladder cancer cells: knocking down the hallmark traits of malignancy. 2016 May 6
29 26764527 A phase I trial of the intravenous Hsp90 inhibitor alvespimycin (17-DMAG) in patients with relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma. 2016 Sep 2
30 26786409 Hypoxia attenuates Hsp90 inhibitor 17-DMAG-induced cyclin B1 accumulation in hepatocellular carcinoma cells. 2016 Mar 1
31 26872308 Acquired resistance to HSP90 inhibitor 17-AAG and increased metastatic potential are associated with MUC1 expression in colon carcinoma cells. 2016 Jun 1
32 27013225 Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer. 2016 2
33 27107422 Hsp90 inhibition increases SOCS3 transcript and regulates migration and cell death in chronic lymphocytic leukemia. 2016 May 10 1
34 27170753 HSP90 Chaperoning in Addition to Phosphoprotein Required for Folding but Not for Supporting Enzymatic Activities of Measles and Nipah Virus L Polymerases. 2016 Aug 1 2
35 27268613 Targeting HSP90 Gene Expression with 17-DMAG Nanoparticles in Breast Cancer Cells. 2016 2
36 27489107 Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery. 2016 Sep 16 1
37 27563925 Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90. 2016 Aug 24 3
38 25739426 Heat shock protein 90 is required for ex vivo neutrophil-driven autoantibody-induced tissue damage in experimental epidermolysis bullosa acquisita. 2015 Jun 1
39 25855731 Molecular chaperone Hsp90 is a therapeutic target for noroviruses. 2015 Jun 6
40 25920748 The HSP90 inhibitor alvespimycin enhances the potency of telomerase inhibition by imetelstat in human osteosarcoma. 2015 2
41 25940182 [Co-inhibition effect of 17-DMAG and oxaliplatin on proliferation and invasion of colorectal cancer cells]. 2015 Apr 2
42 26219569 P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement. 2015 Jul 29 2
43 24293393 The growth inhibitory effect of 17-DMAG on ALK and MYCN double-positive neuroblastoma cell line. 2014 Apr 1
44 24418474 Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases. 2014 Jan 13 1
45 24671949 In vivo fluorescence lifetime imaging for monitoring the efficacy of the cancer treatment. 2014 Jul 1 1
46 24694060 Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations. 2014 Apr 2 1
47 24784839 FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism. 2014 Jul 1
48 24796797 Hsp90 blockade modulates bullous pemphigoid IgG-induced IL-8 production by keratinocytes. 2014 Nov 1
49 24961936 Immunomodulatory effects of heat shock protein 90 inhibition on humoral immune responses. 2014 Aug 1
50 25153785 Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration. 2014 Oct 1