Imatinib Mesylate

KIT ligand ; Homo sapiens







48 Article(s)
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1 34775854 Vitreous hemorrhage: A rare ophthalmic adverse effect due to imatinib treatment. 2022 Apr 1
2 33030616 Apatinib exhibits synergistic effect with pyrotinib and reverses acquired pyrotinib resistance in HER2-positive gastric cancer via stem cell factor/c-kit signaling and its downstream pathways. 2021 Mar 1
3 30864679 [Corrigendum] Antiproliferative effects of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF expression. 2019 May 1
4 31138788 A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer. 2019 May 28 1
5 29620139 Antiproliferative effects of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF expression. 2018 Jul 1
6 30396237 Inhibition of MicroRNA-221 and 222 Enhances Hematopoietic Differentiation from Human Pluripotent Stem Cells via c-KIT Upregulation. 2018 Nov 30 1
7 28260860 Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes. 2017 3
8 25605011 Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia. 2015 Feb 20 2
9 25985771 Predicting Effectiveness of Imatinib Mesylate in Tumors Expressing Platelet-Derived Growth Factors (PDGF-AA, PDGF-BB), Stem Cell Factor Ligands and Their Respective Receptors (PDGFR-α, PDGFR-β, and c-kit). 2015 Sep 4
10 26474484 C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways. 2015 1
11 24333732 Imatinib sensitizes endometrial cancer cells to cisplatin by targeting CD117-positive growth-competent cells. 2014 Apr 1 1
12 24479586 Inhibitory effects of imatinib mesylate on human epidermal melanocytes. 2014 Mar 2
13 24652072 Mechanisms of resistance to imatinib mesylate in KIT-positive metastatic uveal melanoma. 2014 Jun 1
14 23278880 Heterogeneity in the responses of human lung mast cells to stem cell factor. 2013 Jan 1
15 23420128 Expression of stem cell factor in gastrointestinal stromal tumors: Implications for proliferation and imatinib resistance. 2013 Feb 5
16 23637779 Tyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocket. 2013 2
17 23749045 Autocrine insulin-like growth factor 1 and stem cell factor but not interleukin 6 support self-renewal of human myeloma cells. 2013 Jun 7 1
18 22314612 Regulation of cell proliferation through a KIT-mediated mechanism in benign prostatic hyperplasia. 2012 Oct 1 1
19 20846303 The role of stem cell factor and c-KIT in keloid pathogenesis: do tyrosine kinase inhibitors have a potential therapeutic role? 2011 Feb 1
20 19703239 Development of lichen sclerosus et atrophicus while receiving a therapeutic dose of imatinib mesylate for chronic myelogenous leukemia. 2010 Aug 1
21 19956885 Imatinib mesylate (STI571) enhances amrubicin-induced cytotoxic activity through inhibition of the phosphatidylinositol 3-kinase/Akt pathway in small cell lung cancer cells. 2010 Jan 2
22 20305142 Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex. 2010 Aug 1
23 19118061 Overexpression of the KIT/SCF in uveal melanoma does not translate into clinical efficacy of imatinib mesylate. 2009 Jan 1 1
24 16521182 STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line, GIST-T1. 2006 Feb 7 1
25 16818499 Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells. 2006 Jun 1
26 16823786 PKC and cAMP positively modulate alkaline-induced exocytosis in the human mast cell line HMC-1. 2006 Dec 15 1
27 16964380 KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and outcomes. 2006 Oct 1
28 17044945 The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells. 2006 Oct 18 5
29 27265480 The effect of imatinib mesylate on the erythroid colony formation from patients with polycythemia vera in the presence of different cytokines. 2006 Sep 5 2
30 15637141 Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib. 2005 Apr 15 2
31 15800027 Synergistic effect of SCF and TNF-alpha on the up-regulation of cell-surface expression of ICAM-1 on human leukemic mast cell line (HMC)-1 cells. 2005 Jul 1
32 16210056 Stem cell factor stimulates the chemotaxis, integrin upregulation, and survival of human basophils. 2005 Oct 2
33 14985355 Stem cell factor/c-kit signaling promotes the survival, migration, and capillary tube formation of human umbilical vein endothelial cells. 2004 Apr 30 1
34 15070666 Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib. 2004 Apr 15 6
35 15141010 The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. 2004 May 1
36 15322333 Stem cell factor and H2O2 induce GLUT1 translocation in M07e cells. 2004 1
37 15511212 Modulation of c-Kit/SCF pathway leads to alterations in topoisomerase-I activity in small cell lung cancer. 2004 1
38 12475982 The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. 2003 Feb 14 1
39 12616857 [Preclinical and clinical profile of imatinib mesilate, a potent protein-tyrosine kinase inhibitor for CML therapy]. 2003 Feb 4
40 12800187 c-Kit is preferentially expressed in MYCN-amplified neuroblastoma and its effect on cell proliferation is inhibited in vitro by STI-571. 2003 Aug 20 1
41 12901973 Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit. 2003 Aug 2
42 12960256 STI571 inhibits growth and adhesion of human mast cells in culture. 2003 Dec 1
43 14635084 Imatinib mesylate causes hypopigmentation in the skin. 2003 Dec 1 2
44 12134042 Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells. 2002 Aug 1
45 11751479 Effects of signal transduction inhibitor 571 in acute myelogenous leukemia cells. 2001 Dec 1
46 12578590 [Low Concentrations of STI571 Enhances beta1 Integrin Mediated Inhibitory Effect on Proliferation of Myeloid Progenitors in Ph(+)Chronic Myeloid Leukemia] 2001 Sep 1
47 10955819 The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth. 2000 Aug 3
48 10991971 Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. 2000 Oct 2